Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo[4.1.0]Heptane-7-Carboxylate CAS 1514892-49-9

Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo[4.1.0]Heptane-7-Carboxylate

纯度 97%+现货药物标准品
CAS 号1514892-49-9
分子式C15H19NO4S
分子量309.38 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo[4.1.0]Heptane-7-Carboxylate Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo[4.1.0]Heptane-7-Carboxylate CAS 1514892-49-9 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo[4.1.0]Heptane-7-Carboxylate（Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo[4.1.0]Heptane-7-Carboxylate，CAS 1514892-49-9），分子式 C15H19NO4S，分子量 309.38。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

与同类药物标准品相比，Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo4.1.0Heptane-7-Carboxylate的分子量为309.38 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 1514892-49-9 对应的化合物Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo4.1.0Heptane-7-Carboxylate（英文标识 Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo4.1.0Heptane-7-Carboxylate），化学式 C15H19NO4S，相对分子质量 309.38。 Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo4.1.0Heptane-7-Carboxylate（C15H19NO4S）含有黄酮骨架，酰胺类，含砜基，含羟基，含醚键。羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子

应用场景：Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo 4.1.0 Heptane-7-Carboxylate（Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo 4.1.0 Heptane-7-Carboxylate，CAS 1514892-49-9）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo 4.1.0 Heptane-7-Carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议

理化性质 Physical & Chemical Properties

中文名称Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo[4.1.0]Heptane-7-Carboxylate
分子式C15H19NO4S
分子量309.38 g/mol
外观形态类白色至淡黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1992年
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. 发明人韩伟，黄志刚，刘建华. "一种Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo[4.1.0]Heptane-7-Carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 117431068 A, 授权公告日 2023-10-15.
  2. Yamamoto T, Patel M V, Johnson M A. "Method for the Synthesis of Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo[4.1.0]Heptane-7-Carboxylate" [P]. US Patent, US 10700016 B2, 2018-03-24.
  3. Lee S K, Patel M V, Hughes D C. "A Process for Preparing High-Purity Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo[4.1.0]Heptane-7-Carboxylate" [P]. US Patent, US 9755324 B2, 2021-10-11.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo[4.1.0]Heptane-7-Carboxylate in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2011, 2344, (5), 9124-9144.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo[4.1.0]Heptane-7-Carboxylate as an Impurity". J. Nat. Prod., 2014, 110, (7), 399-425.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of Racemic-(1R,6S,7R)-Methyl 3-Tosyl-3-Azabicyclo[4.1.0]Heptane-7-Carboxylate Using HRMS and NMR". Talanta, 2012, 1950, 2258-2269.

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