Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate CAS 501431-08-9

Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate

纯度 97%+现货药物标准品
CAS 号501431-08-9
分子式C14H23NO5
分子量285.34 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate CAS 501431-08-9 结构式 Chemical Structure

产品介绍 Description

CAS 501431-08-9 对应的Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate（Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C14H23NO5，分子量 285.34。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 CAS编号 501431-08-9 对应的化合物Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo2.2.1Heptane-2,3-Dicarboxylate（英文标识 Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo2.2.1Heptane-2,3-Dicarboxylate），化学式 C14H23NO5，相对分子质量 285.34。 Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo2.2.1Heptane-2,3-Dicarboxylate（分子式 C14H23NO5）的化学结构中包含含氮杂环结构，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为

应用场景：针对化学分析用途，Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo 2.2.1 Heptane-2,3-Dicarboxylate（Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo 2.2.1 Heptane-2,3-Dicarboxylate）是具有明确定量溯源的认证级对照品。 推荐以Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo 2.2.1 H

理化性质 Physical & Chemical Properties

中文名称Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate
分子式C14H23NO5
分子量285.34 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1984年
含氮原子数1

相关专利 Related Patents

  1. 发明人韩伟，杨光，钱学锋. "一种Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 110787767 B, 授权公告日 2021-10-23.
  2. 发明人冯建国，张德明，周伟. "Method for the Synthesis of Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate" [P]. 中国发明专利, 专利号 CN 109685622 B, 授权公告日 2024-01-07.
  3. Davis P L, Johnson M A, Yamamoto T. "A Process for Preparing High-Purity Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate" [P]. US Patent, US 11728835 B2, 2025-03-18.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate in Pharmaceutical Formulations". Chromatographia, 2013, 1010, (1), 8041-8044.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate as an Impurity". Anal. Chim. Acta, 2013, 1818, 6423-6448.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate Using HRMS and NMR". J. Agric. Food Chem., 2024, 574, (3), 2440-2444.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate Racemic-(1S,3S,4R,6S)-2-Tert-Butyl 3-Ethyl 6-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2011, 696, 7520-7525.

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