CAS 1639139-65-3

[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl] N-[2-[[4-[[(2S)-6-amino-2-[[(2S)-2-[[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-[[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxo-ethoxy]acetyl]amino]-3-phenyl-propanoyl]amino]hexanoyl]amino]phenyl]methoxycarbonyl-methyl-amino]ethyl]-N-methyl-carbamate

纯度 97%+现货药物标准品
CAS 号1639139-65-3
分子式C87H116N14O24
分子量1741.93 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl] N-[2-[[4-[[(2S)-6-amino-2-[[(2S)-2-[[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-[[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxo-ethoxy]acetyl]amino]-3-phenyl-propanoyl]amino]hexanoyl]amino]phenyl]methoxycarbonyl-methyl-amino]ethyl]-N-methyl-carbamate CAS 1639139-65-3 结构式 Chemical Structure

产品介绍 Description

（[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl] N-[2-[[4-[[(2S)-6-amino-2-[[(2S)-2-[[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-[[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxo-ethoxy]acetyl]amino]-3-phenyl-propanoyl]amino]hexanoyl]amino]phenyl]methoxycarbonyl-methyl-amino]ethyl]-N-methyl-carbamate，CAS 号 1639139-65-3）是 CATO 佳途自主生产的药物标准品，分子式 C87H116N14O24，分子量 1741.93。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括在内的目标物的控制。 （(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo11.8.0.0²¹¹.0⁴⁹.0¹⁵²ºhenicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl N-2-4-(2S)-6-amino-2-(2S)-2-2-2-2-2-2-2-2-2-2-2-2-4-4-(2,5-dioxopyrrol-1-yl)methylcyclohexanecarbonylaminomethyltriazol-1-ylethoxyethoxyethoxyethoxyethoxyethoxyethoxyethoxyethylamino-2-oxo-ethoxyacetylamino-3-phenyl-propanoylaminohexanoylaminophenylmethoxycarbonyl-methy

应用场景：（ (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo 11.8.0.0²¹¹.0⁴⁹.0¹⁵²º henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl N- 2- 4- (2S)-6-amino-2- (2S)-2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 4- 4- (2,5-dioxopyrrol-1-yl)methyl cyclohexanecarbonyl amino methyl triazol-1-yl ethox

理化性质 Physical & Chemical Properties

中文名称
分子式C87H116N14O24
分子量1741.93 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）37.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1993年
含氮原子数14

相关专利 Related Patents

  1. 发明人胡光，何建平，朱建伟. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 108116627 B, 授权公告日 2022-02-24.
  2. 发明人徐明华，陈志强，沈红梅. "Method for the Synthesis of [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl] N-[2-[[4-[[(2S)-6-amino-2-[[(2S)-2-[[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-[[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxo-ethoxy]acetyl]amino]-3-phenyl-propanoyl]amino]hexanoyl]amino]phenyl]methoxycarbonyl-methyl-amino]ethyl]-N-methyl-carbamate" [P]. 中国发明专利, 专利号 CN 113500971 A, 授权公告日 2019-12-27.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Environ. Sci. Technol., 2022, 337, (10), 6169-6195.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". J. Agric. Food Chem., 2024, 1603, (5), 8362-8375.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl] N-[2-[[4-[[(2S)-6-amino-2-[[(2S)-2-[[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-[[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxo-ethoxy]acetyl]amino]-3-phenyl-propanoyl]amino]hexanoyl]amino]phenyl]methoxycarbonyl-methyl-amino]ethyl]-N-methyl-carbamate Using HRMS and NMR". Food Chem., 2021, 2180, (9), 6303-6315.

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