CAS 2765424-54-0

[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl] N-[2-[[4-[[(2S)-2-[[(2S)-2-[2-[2-[2-[[(1R,8S)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylsulfamoylamino]ethoxy]ethoxycarbonylsulfamoyl-[2-[[(1S)-1-[[(1S)-1-[[4-[[2-[[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]oxycarbonyl-methyl-amino]ethyl-methyl-carbamoyl]oxymethyl]phenyl]carbamoyl]-4-ureido-butyl]carbamoyl]-2-methyl-propyl]carbamoyloxy]ethyl]amino]ethoxycarbonylamino]-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methoxycarbonyl-methyl-amino]ethyl]-N-methyl-carbamate

纯度 97%+现货药物标准品
CAS 号2765424-54-0
分子式C114H144N22O35S2
分子量2446.62 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl] N-[2-[[4-[[(2S)-2-[[(2S)-2-[2-[2-[2-[[(1R,8S)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylsulfamoylamino]ethoxy]ethoxycarbonylsulfamoyl-[2-[[(1S)-1-[[(1S)-1-[[4-[[2-[[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]oxycarbonyl-methyl-amino]ethyl-methyl-carbamoyl]oxymethyl]phenyl]carbamoyl]-4-ureido-butyl]carbamoyl]-2-methyl-propyl]carbamoyloxy]ethyl]amino]ethoxycarbonylamino]-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methoxycarbonyl-methyl-amino]ethyl]-N-methyl-carbamate CAS 2765424-54-0 结构式 Chemical Structure

产品介绍 Description

（英文名 [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl] N-[2-[[4-[[(2S)-2-[[(2S)-2-[2-[2-[2-[[(1R,8S)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylsulfamoylamino]ethoxy]ethoxycarbonylsulfamoyl-[2-[[(1S)-1-[[(1S)-1-[[4-[[2-[[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]oxycarbonyl-methyl-amino]ethyl-methyl-carbamoyl]oxymethyl]phenyl]carbamoyl]-4-ureido-butyl]carbamoyl]-2-methyl-propyl]carbamoyloxy]ethyl]amino]ethoxycarbonylamino]-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methoxycarbonyl-methyl-amino]ethyl]-N-methyl-carbamate，CAS 2765424-54-0）属于药物标准品。分子式 C114H144N22O35S2，分子量 2446.62。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

化学式为 C114H144N22O35S2 的（(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo11.8.0.0²¹¹.0⁴⁹.0¹⁵²ºhenicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl N-2-4-(2S)-2-(2S)-2-2-2-2-(1R,8S)-9-bicyclo6.1.0non-4-ynylmethoxycarbonylsulfamoylaminoethoxyethoxycarbonylsulfamoyl-2-(1S)-1-(1S)-1-4-2-(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo11.8.0.0²¹¹.0⁴⁹.0¹⁵²ºhenicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yloxycarbonyl-methyl-aminoethyl-

应用场景：（ (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo 11.8.0.0²¹¹.0⁴⁹.0¹⁵²º henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl N- 2- 4- (2S)-2- (2S)-2- 2- 2- 2- (1R,8S)-9-bicyclo 6.1.0 non-4-ynyl methoxycarbonylsulfamoylamino ethoxy ethoxycarbonylsulfamoyl- 2- (1S)-1- (1S)-1- 4

理化性质 Physical & Chemical Properties

中文名称
分子式C114H144N22O35S2
分子量2446.62 g/mol
外观形态淡黄色至黄色无定形粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）54.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2003年
含氮原子数22
含硫原子数2

相关专利 Related Patents

  1. 发明人冯建国，李文辉，唐晓军. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 114892887 A, 授权公告日 2022-06-08.
  2. 发明人徐明华，马晓峰，郭海燕. "Method for the Synthesis of [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl] N-[2-[[4-[[(2S)-2-[[(2S)-2-[2-[2-[2-[[(1R,8S)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylsulfamoylamino]ethoxy]ethoxycarbonylsulfamoyl-[2-[[(1S)-1-[[(1S)-1-[[4-[[2-[[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]oxycarbonyl-methyl-amino]ethyl-methyl-carbamoyl]oxymethyl]phenyl]carbamoyl]-4-ureido-butyl]carbamoyl]-2-methyl-propyl]carbamoyloxy]ethyl]amino]ethoxycarbonylamino]-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methoxycarbonyl-methyl-amino]ethyl]-N-methyl-carbamate" [P]. 中国发明专利, 专利号 CN 114486035 B, 授权公告日 2020-03-16.
  3. 发明人赵玉洁，冯建国，陈志强. "A Process for Preparing High-Purity [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl] N-[2-[[4-[[(2S)-2-[[(2S)-2-[2-[2-[2-[[(1R,8S)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylsulfamoylamino]ethoxy]ethoxycarbonylsulfamoyl-[2-[[(1S)-1-[[(1S)-1-[[4-[[2-[[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]oxycarbonyl-methyl-amino]ethyl-methyl-carbamoyl]oxymethyl]phenyl]carbamoyl]-4-ureido-butyl]carbamoyl]-2-methyl-propyl]carbamoyloxy]ethyl]amino]ethoxycarbonylamino]-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methoxycarbonyl-methyl-amino]ethyl]-N-methyl-carbamate" [P]. 中国发明专利, 专利号 CN 113237297 B, 授权公告日 2023-03-20.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Nat. Prod., 2025, 221, (10), 2187-2193.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Chemosphere, 2011, 1568, (10), 7373-7391.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl] N-[2-[[4-[[(2S)-2-[[(2S)-2-[2-[2-[2-[[(1R,8S)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylsulfamoylamino]ethoxy]ethoxycarbonylsulfamoyl-[2-[[(1S)-1-[[(1S)-1-[[4-[[2-[[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]oxycarbonyl-methyl-amino]ethyl-methyl-carbamoyl]oxymethyl]phenyl]carbamoyl]-4-ureido-butyl]carbamoyl]-2-methyl-propyl]carbamoyloxy]ethyl]amino]ethoxycarbonylamino]-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methoxycarbonyl-methyl-amino]ethyl]-N-methyl-carbamate Using HRMS and NMR". Anal. Methods, 2012, 553, 5018-5026.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Molecules, 2021, 802, (1), 307-319.

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