Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate CAS 175277-03-9

Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate

纯度 97%+现货药物标准品
CAS 号175277-03-9
分子式C14H22F3NO2S
分子量325.39 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate CAS 175277-03-9 结构式 Chemical Structure

产品介绍 Description

Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate（Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate）是药物分析与质量控制领域常用的药物标准品，CAS 号 175277-03-9。分子式 C14H22F3NO2S，分子量 325.39。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

作为认证标准物质（CRM），Ethyl 4-methyl-2-4-(trifluoro-methyl)-phenylthiazole-5-carboxylate满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 CAS编号 175277-03-9 对应的化合物Ethyl 4-methyl-2-4-(trifluoro-methyl)-phenylthiazole-5-carboxylate（英文标识 Ethyl 4-methyl-2-4-(trifluoro-methyl)-phenylthiazole-5-carboxylate），化学式 C14H22F3NO2S，相对分子质量 325.39。 从化学结构特征来看，Ethyl 4-methyl-2-4-(trifluoro-methyl)-phenylthiazole-5-carboxylate的分子骨架中包含酰胺类，含砜基，羧酸类，含羟基，含醚键，含氟取代。该化合物的不饱和度为

应用场景：针对化学分析用途，Ethyl 4-methyl-2- 4-(trifluoro-methyl)-phenyl thiazole-5-carboxylate（Ethyl 4-methyl-2- 4-(trifluoro-methyl)-phenyl thiazole-5-carboxylate）是具有明确定量溯源的认证级对照品。 推荐以Ethyl 4-methyl-2- 4-(trifluoro-methyl)-phenyl thiazole-5-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级

理化性质 Physical & Chemical Properties

中文名称Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate
分子式C14H22F3NO2S
分子量325.39 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）2007年
卤素含量F取代
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. 发明人郭海燕，唐晓军，胡光. "一种Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 117004347 B, 授权公告日 2018-03-10.
  2. Nielsen H, Schröder R, Johansson L. "Method for the Synthesis of Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate" [P]. European Patent, EP 3808685 A1, 2024-03-26.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate in Pharmaceutical Formulations". Chromatographia, 2011, 1583, 9058-9079.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate as an Impurity". J. Sep. Sci., 2023, 325, (2), 6446-6461.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate Using HRMS and NMR". Molecules, 2024, 2148, (10), 2649-2657.

推荐产品 Recommended Standards

为什么选择 CATO 佳途？

加载产品详情...