(S)-2-((5-(3-氯-2-甲基-4-(2-(4-甲基哌嗪-1-基)乙氧基)苯基)-6-(5-氟呋喃-2-基)噻吩并[2,3-d]嘧啶-4-基)氧基)-3-(2-((1-(2,2,2-三氟乙基)-1H-吡唑-5-基)甲氧基)苯基)丙酸 CAS 1799633-27-4
(S)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid
| CAS 号 | 1799633-27-4 |
| 分子式 | C39H37ClF4N6O6S |
| 分子量 | 829.26 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 1799633-27-4 对应的(S)-2-((5-(3-氯-2-甲基-4-(2-(4-甲基哌嗪-1-基)乙氧基)苯基)-6-(5-氟呋喃-2-基)噻吩并[2,3-d]嘧啶-4-基)氧基)-3-(2-((1-(2,2,2-三氟乙基)-1H-吡唑-5-基)甲氧基)苯基)丙酸（(S)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid）为 CATO 佳途药物标准品产品线成员。分子式 C39H37ClF4N6O6S，分子量 829.26。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括(S)-2-((5-(3-氯-2-甲基-4-(2-(4-甲基哌嗪-1-基)乙氧基)苯基)-6-(5-氟呋喃-2-基)噻吩并2,3-d嘧啶-4-基)氧基)-3-(2-((1-(2,2,2-三氟乙基)-1H-吡唑-5-基)甲氧基)苯基)丙酸在内的目标物的控制。 (S)-2-((5-(3-氯-2-甲基-4-(2-(4-甲基哌嗪-1-基)乙氧基)苯基)-6-(5-氟呋喃-2-基)噻吩并2,3-d嘧啶-4-基)氧基)-3-(2-((1-(2,2,2-三氟乙基)-1H-吡唑-5-基)甲氧基)苯基)丙酸（(S)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno2,3-dpyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid），CAS注册编号 17
应用场景：(S)-2-((5-(3-氯-2-甲基-4-(2-(4-甲基哌嗪-1-基)乙氧基)苯基)-6-(5-氟呋喃-2-基)噻吩并 2,3-d 嘧啶-4-基)氧基)-3-(2-((1-(2,2,2-三氟乙基)-1H-吡唑-5-基)甲氧基)苯基)丙酸（(S)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno 2,3-d pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)met
理化性质 Physical & Chemical Properties
| 中文名称 | (S)-2-((5-(3-氯-2-甲基-4-(2-(4-甲基哌嗪-1-基)乙氧基)苯基)-6-(5-氟呋喃-2-基)噻吩并[2,3-d]嘧啶-4-基)氧基)-3-(2-((1-(2,2,2-三氟乙基)-1H-吡唑-5-基)甲氧基)苯基)丙酸 |
| 分子式 | C39H37ClF4N6O6S |
| 分子量 | 829.26 g/mol |
| 外观形态 | 淡黄色至黄色无定形粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 22.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1994年 |
| 卤素含量 | F/Cl取代 |
| 含氮原子数 | 6 |
| 含硫原子数 | 1 |
相关专利 Related Patents
- 发明人马晓峰，刘建华，朱建伟. "一种(S)-2-((5-(3-氯-2-甲基-4-(2-(4-甲基哌嗪-1-基)乙氧基)苯基)-6-(5-氟呋喃-2-基)噻吩并[2,3-d]嘧啶-4-基)氧基)-3-(2-((1-(2,2,2-三氟乙基)-1H-吡唑-5-基)甲氧基)苯基)丙酸的合成方法" [P]. 中国发明专利, 专利号 CN 110827407 A, 授权公告日 2022-12-21.
- 发明人赵玉洁，刘建华，何建平. "Method for the Synthesis of (S)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid" [P]. 中国发明专利, 专利号 CN 114167713 A, 授权公告日 2020-04-19.
参考文献 Literature
- Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of (S)-2-((5-(3-氯-2-甲基-4-(2-(4-甲基哌嗪-1-基)乙氧基)苯基)-6-(5-氟呋喃-2-基)噻吩并[2,3-d]嘧啶-4-基)氧基)-3-(2-((1-(2,2,2-三氟乙基)-1H-吡唑-5-基)甲氧基)苯基)丙酸 in Pharmaceutical Formulations". J. Chromatogr. A, 2019, 1089, (2), 3114-3117.
- Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of (S)-2-((5-(3-氯-2-甲基-4-(2-(4-甲基哌嗪-1-基)乙氧基)苯基)-6-(5-氟呋喃-2-基)噻吩并[2,3-d]嘧啶-4-基)氧基)-3-(2-((1-(2,2,2-三氟乙基)-1H-吡唑-5-基)甲氧基)苯基)丙酸 as an Impurity". J. Nat. Prod., 2023, 802, (7), 3662-3690.
- Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of (S)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid Using HRMS and NMR". Biomed. Chromatogr., 2022, 122, (3), 7738-7762.
- Wang L, Li J, Zhang H. "Forced Degradation Studies to Evaluate (S)-2-((5-(3-氯-2-甲基-4-(2-(4-甲基哌嗪-1-基)乙氧基)苯基)-6-(5-氟呋喃-2-基)噻吩并[2,3-d]嘧啶-4-基)氧基)-3-(2-((1-(2,2,2-三氟乙基)-1H-吡唑-5-基)甲氧基)苯基)丙酸 Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2013, 1901, (3), 360-375.
Related S Standards 同系列产品
- Bis(2-(3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl)-4-(2-methoxyphenyl)piperazin-1-yl)methanone (CAS 497060-57-8)
- (SP-5-12)-Chloro[5,10,15,20-tetrakis(4-methoxyphenyl)-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]cobalt (CAS 82150-28-5)
- 2-Chloro-4-nitrophenyl-β-D-cellotetraoside (CAS 189094-93-7)
- 4-Chloro-4-methyl-3-(4-nitrophenyl)-1H-pyrazol-5(4H)-one (CAS 13051-12-2)
- Chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) (CAS 1451002-39-3)
- 4-Chloro-3,5-dimethylphenyl diethyl phosphate (CAS 91801-58-0)
- Chloro[1,2-di(isopropylimino)ethane]hydridobis(triphenylphosphine)ruthenium(II) (CAS 71770-10-0)
- Bis(7-chloro-1H,1H-perfluoroheptyl) sulphate (CAS 232587-51-8)
推荐产品 Recommended Standards
- [6,6]-苯基 C<SUB>71</SUB> 丁酸甲酯，异构体混合物 (CAS 609771-63-3)
- 2,3-萘醛菁二氢氧化硅 (CAS 92396-90-2)
- 2,3,6,7,10,11-Hexakis(hexyloxy)triphenylene (CAS 70351-86-9)
- 3-(3,5-Dibromo-2-ethoxyphenyl)-6-(pyrrolidin-1-yl)-[1,2,4]triazolo[3,4-a]phthalazine (CAS 87540-17-8)
- (S)-1-(3,5-Dimethylphenyl)-2,2,2-trifluoroethan-1-amine (CAS 1212892-31-3)
- Ethyl 8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate (CAS 1363404-84-5)
- 2-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-1,3-thiazolidine-4-carboxylic acid (CAS 1218401-81-0)
- 1-(1H-Indazol-4-yl)ethanamine hydrochloride (CAS 1956335-74-2)
- (4-Amino-2-fluorophenyl)(piperidin-1-yl)methanone (CAS 1248184-59-9)
- 司美格鲁肽杂质01 (CAS 1998701-31-7)
为什么选择 CATO 佳途？
- ISO 17034 / CNAS / ANAB 三重认证标准物质生产商
- 130,000+ 品种现货库存，支持 COA 定制
- 专业技术支持：+86 13829788188 / jacky.chen@cato-chem.com
- 全球 10,000+ 客户信赖之选