trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate CAS 1803589-98-1

trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate

纯度 97%+现货药物标准品
CAS 号1803589-98-1
分子式C9H9N3O2 C2HF3O2
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate CAS 1803589-98-1 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate（trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate）为药物标准品，CAS 登记号 1803589-98-1，分子式 C9H9N3O2 C2HF3O2。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

从化学结构特征来看，trifluoroacetic acid methyl 5-methyl-3H-imidazo4,5-bpyridine-7-carboxylate的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代。该化合物的不饱和度为7.0，表明结构中存在约7个环或双键等价单元。分子量为305.21 g/mol，属于较高分子量化合物。卤素原子的引入增加了化合物的电负性，在ECD（电子捕获检测器）中具有优良的响应灵敏度。 化学式为 C9H9N3O2 C2HF3O2 的trifluoroacetic acid methyl 5-methyl-3H-imidazo4,5-bpyridine-7-carboxylate（trifluoroacetic acid methyl 5-methyl-3H-imidazo4,5-bpyridine-7-carboxylate），其CAS登记号是 1803589-98-1，分子量为 305.21 g/mol。 本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准

应用场景：trifluoroacetic acid methyl 5-methyl-3H-imidazo 4,5-b pyridine-7-carboxylate（trifluoroacetic acid methyl 5-methyl-3H-imidazo 4,5-b pyridine-7-carboxylate）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以trifluoroacetic acid methyl 5-methyl-3H-imidazo 4,5-b pyridine-7-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1

理化性质 Physical & Chemical Properties

中文名称trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate
分子式C9H9N3O2 C2HF3O2
分子量305.21 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. 发明人钱学锋，杨光，刘建华. "一种trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 110638219 B, 授权公告日 2020-07-07.
  2. 发明人李文辉，韩伟，冯建国. "Method for the Synthesis of trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate" [P]. 中国发明专利, 专利号 CN 114396567 A, 授权公告日 2025-10-25.
  3. 发明人林芳，韩伟，赵玉洁. "A Process for Preparing High-Purity trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate" [P]. 中国发明专利, 专利号 CN 110141750 B, 授权公告日 2018-08-23.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate in Pharmaceutical Formulations". Biomed. Chromatogr., 2014, 2182, (9), 7977-8005.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate as an Impurity". J. Chromatogr. A, 2015, 1952, 7981-8011.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate Using HRMS and NMR". J. Agric. Food Chem., 2012, 1111, 5627-5644.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate trifluoroacetic acid methyl 5-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylate Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2025, 1900, (9), 7091-7099.

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