3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride CAS 1803600-63-6

3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride

纯度 97%+现货药物标准品
CAS 号1803600-63-6
分子式C6H8F2N4 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride 3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride CAS 1803600-63-6 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride（3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride）为药物标准品，CAS 登记号 1803600-63-6，分子式 C6H8F2N4 2*HCl。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 化学式为 C6H8F2N4 2HCl 的3-(difluoromethyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyrazine dihydrochloride（3-(difluoromethyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyrazine dihydrochloride），其CAS登记号是 1803600-63-6，分子量为 210.61 g/mol。 3-(difluoromethyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyrazine dihydrochloride（C6H8F2N4 2HCl）含有含氰基，含氟/氯取代。卤素取代增加了化合物的密度和沸点，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。由于结构中存在共轭发色团，该化合物在200-400 nm区间具有显著的紫外吸收，便于HPLC-UV检测。

应用场景：3-(difluoromethyl)-5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyrazine dihydrochloride（3-(difluoromethyl)-5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyrazine dihydrochloride，CAS 1803600-63-6）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以3-(difluoromethyl)-5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyrazine dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现

理化性质 Physical & Chemical Properties

中文名称3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride
分子式C6H8F2N4 2*HCl
分子量210.61 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1995年
卤素含量F/Cl取代
含氮原子数4

相关专利 Related Patents

  1. Kumar R, Schröder R, Chen K W. "一种3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride的合成方法" [P]. US Patent, US 10771446 B2, 2024-03-07.
  2. Anderson J P, Hughes D C, Yamamoto T. "Method for the Synthesis of 3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride" [P]. US Patent, US 11655314 B2, 2018-12-24.
  3. 发明人胡光，陈志强，郑宇鹏. "A Process for Preparing High-Purity 3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride" [P]. 中国发明专利, 专利号 CN 114596517 A, 授权公告日 2019-09-24.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride in Pharmaceutical Formulations". Molecules, 2023, 401, 5365-5368.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride as an Impurity". Anal. Methods, 2020, 165, (10), 2605-2622.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride Using HRMS and NMR". Anal. Chem., 2019, 2111, (4), 4165-4188.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2019, 320, (4), 7242-7255.

Related difluoromethyl Standards 同系列产品

推荐产品 Recommended Standards

为什么选择 CATO 佳途？

加载产品详情...