{[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine CAS 1820579-84-7

{[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine

纯度 97%+现货药物标准品
CAS 号1820579-84-7
分子式C11H19FN4
分子量226.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

{[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine {[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine CAS 1820579-84-7 结构式 Chemical Structure

产品介绍 Description

{[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine（{[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine）是药物分析与质量控制领域常用的药物标准品，CAS 号 1820579-84-7。分子式 C11H19FN4，分子量 226.29。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，{cis-4-fluoro-1-(1-methyl-1H-pyrazol-4-yl)methylpyrrolidin-2-ylmethyl}(methyl)amine的分子量为226.29 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 1820579-84-7 对应的化合物{cis-4-fluoro-1-(1-methyl-1H-pyrazol-4-yl)methylpyrrolidin-2-ylmethyl}(methyl)amine（英文标识 {cis-4-fluoro-1-(1-methyl-1H-pyrazol-4-yl)methylpyrrolidin-2-ylmethyl}(methyl)amine），化学式 C11H19FN4，相对分子质量 226.29。 依据分子式为 C11H19FN4 的{cis-4-fluoro-1-(1-methyl-1H-pyrazol-4-yl)methylpyrrolidin-2-ylmethyl}(methyl)amine结构特征，其分子内含含氮

应用场景：{ cis-4-fluoro-1- (1-methyl-1H-pyrazol-4-yl)methyl pyrrolidin-2-yl methyl}(methyl)amine（{ cis-4-fluoro-1- (1-methyl-1H-pyrazol-4-yl)methyl pyrrolidin-2-yl methyl}(methyl)amine，CAS 1820579-84-7）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以{ cis-4-fluoro-1- (1-methyl-1H-pyrazol-4-yl)methyl pyrrolidin-2-yl methyl}(met

理化性质 Physical & Chemical Properties

中文名称{[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine
分子式C11H19FN4
分子量226.29 g/mol
外观形态类白色至淡黄色低熔点固体。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量F取代
含氮原子数4

相关专利 Related Patents

  1. 发明人黄志刚，高志强，冯建国. "一种{[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine的合成方法" [P]. 中国发明专利, 专利号 CN 116535934 A, 授权公告日 2021-09-12.
  2. 发明人孙丽萍，杨光，张德明. "Method for the Synthesis of {[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine" [P]. 中国发明专利, 专利号 CN 109225253 B, 授权公告日 2024-11-26.
  3. Davis P L, Chen K W, Brown S R. "A Process for Preparing High-Purity {[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine" [P]. US Patent, US 10949175 B2, 2020-06-02.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of {[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine in Pharmaceutical Formulations". J. Sep. Sci., 2015, 850, (9), 6707-6732.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of {[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine as an Impurity". J. Chromatogr. A, 2013, 2006, (8), 3377-3394.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of {[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine Using HRMS and NMR". Biomed. Chromatogr., 2022, 609, (7), 778-797.
  4. Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate {[cis-4-fluoro-1-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrrolidin-2-yl]methyl}(methyl)amine Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2022, 1794, 1911-1929.

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