ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate CAS 1909317-05-0

ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate

纯度 97%+现货药物标准品
CAS 号1909317-05-0
分子式C15H14ClFN2O2
分子量308.74 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate CAS 1909317-05-0 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate（ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate，CAS 1909317-05-0），分子式 C15H14ClFN2O2，分子量 308.74。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

与同类药物标准品相比，ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylate的分子量为308.74 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C15H14ClFN2O2 的ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylate（ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylate），其CAS登记号是 1909317-05-0，分子量为 308.74 g/mol。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键，含氟/氯取代的影响，ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylate表现为淡黄色至黄色结晶性粉末。（具

应用场景：ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta c pyrazole-3-carboxylate（ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta c pyrazole-3-carboxylate）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta c pyrazole-3-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法

理化性质 Physical & Chemical Properties

中文名称ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate
分子式C15H14ClFN2O2
分子量308.74 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量F/Cl取代
含氮原子数2

相关专利 Related Patents

  1. Stevens L M, Hughes D C, Park J H. "一种ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate的合成方法" [P]. US Patent, US 11548952 B2, 2025-05-09.
  2. 发明人唐晓军，赵玉洁，周伟. "Method for the Synthesis of ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate" [P]. 中国发明专利, 专利号 CN 114859229 A, 授权公告日 2022-04-24.
  3. 发明人唐晓军，罗永刚，郑宇鹏. "A Process for Preparing High-Purity ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate" [P]. 中国发明专利, 专利号 CN 113180455 A, 授权公告日 2025-10-23.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate in Pharmaceutical Formulations". J. Sep. Sci., 2025, 543, (7), 1458-1485.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate as an Impurity". Anal. Chem., 2010, 1119, (1), 5538-5549.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate Using HRMS and NMR". Phytochemistry, 2016, 1704, (1), 5503-5529.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2014, 2119, (9), 511-527.

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