7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione CAS 1955498-83-5

7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione

纯度 97%+现货药物标准品
CAS 号1955498-83-5
分子式C16H17BrN2O3S
分子量397.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione 7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione CAS 1955498-83-5 结构式 Chemical Structure

产品介绍 Description

CAS 1955498-83-5 对应的7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione（7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione）为 CATO 佳途药物标准品产品线成员。分子式 C16H17BrN2O3S，分子量 397.29。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 CAS编号 1955498-83-5 对应的化合物7-bromo-2-(3-methoxyphenyl)methyl-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione（英文标识 7-bromo-2-(3-methoxyphenyl)methyl-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione），化学式 C16H17BrN2O3S，相对分子质量 397.29。 7-bromo-2-(3-methoxyphenyl)methyl-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione（分子式 C16H17BrN2O3S）的化学结构中包含含氮杂环结构，酰胺类，含砜基，含羟基，含醚键，含溴取代。在反相色谱体系中，其保留行为主要受含氮

应用场景：7-bromo-2- (3-methoxyphenyl)methyl -4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione（7-bromo-2- (3-methoxyphenyl)methyl -4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione，CAS 1955498-83-5）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以7-bromo-2- (3-methoxyphenyl)methyl -4-methyl-3,4-dihydro

理化性质 Physical & Chemical Properties

中文名称7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione
分子式C16H17BrN2O3S
分子量397.29 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1996年
卤素含量Br取代
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. 发明人杨光，赵玉洁，李文辉. "一种7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione的合成方法" [P]. 中国发明专利, 专利号 CN 117061022 B, 授权公告日 2022-09-05.
  2. 发明人胡光，黄志刚，王建平. "Method for the Synthesis of 7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione" [P]. 中国发明专利, 专利号 CN 111586090 B, 授权公告日 2024-07-27.
  3. Fischer A B, Kumar R, Chen K W. "A Process for Preparing High-Purity 7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione" [P]. US Patent, US 9634468 B2, 2022-05-09.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione in Pharmaceutical Formulations". Anal. Chim. Acta, 2017, 1842, 3095-3115.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of 7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione as an Impurity". Phytochemistry, 2017, 2377, (10), 2352-2381.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione Using HRMS and NMR". J. Nat. Prod., 2014, 328, (6), 1192-1202.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 7-bromo-2-[(3-methoxyphenyl)methyl]-4-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2014, 1902, (4), 2270-2284.

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