rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine CAS 1969287-63-5

rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine

纯度 97%+现货药物标准品
CAS 号1969287-63-5
分子式C10H18N4O
分子量210.28 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine CAS 1969287-63-5 结构式 Chemical Structure

产品介绍 Description

rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine（rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine，CAS 号 1969287-63-5）是 CATO 佳途自主生产的药物标准品，分子式 C10H18N4O，分子量 210.28。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-ylmethanamine的分子量为210.28 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 1969287-63-5 对应的化合物rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-ylmethanamine（英文标识 rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-ylmethanamine），化学式 C10H18N4O，相对分子质量 210.28。 依据分子式为 C10H18N4O 的rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-ylmethanamine结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子

应用场景：rac- (2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl methanamine（rac- (2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl methanamine，CAS 1969287-63-5）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以rac- (2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl methanamine配制标准系列工作溶液，用于建立标准曲线实现外标法

理化性质 Physical & Chemical Properties

中文名称rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine
分子式C10H18N4O
分子量210.28 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1996年
含氮原子数4

相关专利 Related Patents

  1. 发明人徐明华，唐晓军，胡光. "一种rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine的合成方法" [P]. 中国发明专利, 专利号 CN 113796324 A, 授权公告日 2023-02-24.
  2. Park J H, Lee S K, Roberts E F. "Method for the Synthesis of rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine" [P]. US Patent, US 10724618 B2, 2017-10-13.
  3. 发明人罗永刚，赵玉洁，沈红梅. "A Process for Preparing High-Purity rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine" [P]. 中国发明专利, 专利号 CN 110897754 A, 授权公告日 2022-01-02.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine in Pharmaceutical Formulations". Anal. Methods, 2011, 393, (1), 9138-9167.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine as an Impurity". J. Pharm. Biomed. Anal., 2022, 2123, 7680-7696.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine Using HRMS and NMR". J. Nat. Prod., 2022, 1515, (1), 636-650.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate rac-[(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)morpholin-2-yl]methanamine Profile in Drug Substances According to ICH Guidelines". Food Chem., 2013, 1787, (11), 4793-4810.

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