1-[(tert-butoxy)carbonyl]-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid CAS 2059932-05-5
1-[(tert-butoxy)carbonyl]-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid
| CAS 号 | 2059932-05-5 |
| 分子式 | C14H17NO5 |
| 分子量 | 279.29 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 2059932-05-5 对应的1-[(tert-butoxy)carbonyl]-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid（1-[(tert-butoxy)carbonyl]-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid）为 CATO 佳途药物标准品产品线成员。分子式 C14H17NO5，分子量 279.29。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括1-(tert-butoxy)carbonyl-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid在内的目标物的控制。 CAS编号 2059932-05-5 对应的化合物1-(tert-butoxy)carbonyl-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid（英文标识 1-(tert-butoxy)carbonyl-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid），化学式 C14H17NO5，相对分子质量 279.29。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键的影响，1-(tert-butoxy)carbonyl-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid表现为类白色至淡黄色结晶性粉末。其固体形态的物理化学属性——包括279.29 g/mol的分子量——对于选择合适的样品前处理方法和分析
应用场景：1- (tert-butoxy)carbonyl -6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid（1- (tert-butoxy)carbonyl -6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以1- (tert-butoxy)carbonyl -6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）
理化性质 Physical & Chemical Properties
| 中文名称 | 1-[(tert-butoxy)carbonyl]-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid |
| 分子式 | C14H17NO5 |
| 分子量 | 279.29 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 7.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1997年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人韩伟，赵玉洁，沈红梅. "一种1-[(tert-butoxy)carbonyl]-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 115350535 A, 授权公告日 2022-03-13.
- 发明人唐晓军，郭海燕，徐明华. "Method for the Synthesis of 1-[(tert-butoxy)carbonyl]-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid" [P]. 中国发明专利, 专利号 CN 111126689 A, 授权公告日 2015-08-08.
- Sørensen M, Martínez F, Johansson L. "A Process for Preparing High-Purity 1-[(tert-butoxy)carbonyl]-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid" [P]. European Patent, EP 3172431 A1, 2020-10-15.
参考文献 Literature
- Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of 1-[(tert-butoxy)carbonyl]-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid in Pharmaceutical Formulations". J. Chromatogr. A, 2022, 2429, 1089-1110.
- Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-[(tert-butoxy)carbonyl]-6-hydroxy-2,3-dihydro-1H-indole-2-carboxylic acid as an Impurity". Chromatographia, 2011, 1136, 2633-2638.
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