5-（[4,6-二氯三嗪-2-基]氨基）荧光素 盐酸盐 CAS 21811-74-5

21811-74-5 Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, ar-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, monohydrochloride Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, hydrochloride (1:1) Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, monohydrochloride 5-((4,6-Dichlorotriazin-2-yl)amino)fluorescein hydrochloride

纯度 97%+现货药物标准品
CAS 号21811-74-5
分子式C23H36Cl2N4O5 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-（[4,6-二氯三嗪-2-基]氨基）荧光素 盐酸盐 21811-74-5 Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, ar-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, monohydrochloride Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, hydrochloride (1:1) Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, monohydrochloride 5-((4,6-Dichlorotriazin-2-yl)amino)fluorescein hydrochloride CAS 21811-74-5 结构式 Chemical Structure

产品介绍 Description

5-（[4,6-二氯三嗪-2-基]氨基）荧光素 盐酸盐（21811-74-5 Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, ar-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, monohydrochloride Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, hydrochloride (1:1) Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, monohydrochloride 5-((4,6-Dichlorotriazin-2-yl)amino)fluorescein hydrochloride，CAS 号 21811-74-5）是 CATO 佳途自主生产的药物标准品，分子式 C23H36Cl2N4O5 HCl。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，5-（4,6-二氯三嗪-2-基氨基）荧光素 盐酸盐的分子量为555.92 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C23H36Cl2N4O5 HCl 的5-（4,6-二氯三嗪-2-基氨基）荧光素 盐酸盐（21811-74-5 Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, ar-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, monohydrochloride Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, hydrochloride (1:1) Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-

应用场景：针对化学分析用途，5-（ 4,6-二氯三嗪-2-基 氨基）荧光素 盐酸盐（21811-74-5 Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, ar-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, monohydrochloride Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, hydrochloride

理化性质 Physical & Chemical Properties

中文名称5-（[4,6-二氯三嗪-2-基]氨基）荧光素 盐酸盐
分子式C23H36Cl2N4O5 HCl
分子量555.92 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1963年
卤素含量Cl取代
含氮原子数4

相关专利 Related Patents

  1. Rossi M, Nielsen H, Martínez F. "一种5-（[4,6-二氯三嗪-2-基]氨基）荧光素 盐酸盐的合成方法" [P]. European Patent, EP 3991231 A1, 2023-04-02.
  2. Davis P L, Klinger H, Johnson M A. "Method for the Synthesis of 21811-74-5 Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, ar-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, monohydrochloride Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, hydrochloride (1:1) Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, monohydrochloride 5-((4,6-Dichlorotriazin-2-yl)amino)fluorescein hydrochloride" [P]. US Patent, US 10636849 B2, 2017-11-16.
  3. 发明人朱建伟，郑宇鹏，陈志强. "A Process for Preparing High-Purity 21811-74-5 Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, ar-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, monohydrochloride Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, hydrochloride (1:1) Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-3',6'-dihydroxy-, monohydrochloride 5-((4,6-Dichlorotriazin-2-yl)amino)fluorescein hydrochloride" [P]. 中国发明专利, 专利号 CN 115782682 A, 授权公告日 2015-05-01.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of 5-（[4,6-二氯三嗪-2-基]氨基）荧光素 盐酸盐 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2017, 978, (12), 1192-1197.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-（[4,6-二氯三嗪-2-基]氨基）荧光素 盐酸盐 as an Impurity". Sci. Total Environ., 2010, 1291, 2886-2895.

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