3′-脱氧-3′-氟胸苷 CAS 25526-93-6

25526-93-6 PG53R0DWDQ Alovudine Alovudine [USAN:INN] 3'-Fluorothymidine Thymidine, 3'-deoxy-3'-fluoro- BRN 0754299 CL 184824 3'-Deoxy-3'-fluorothymidine FLT 3'-Fluorodeoxythymidine 3'-Fluoro-3'-deoxythymidine NSC 140025 FddT DRG-0097 1-(3'-Deoxy-3'-fluoro-beta-D-pentofuranosyl)thymine UNII-PG53R0DWDQ CL 184,824 3'-Deoxy-3'-18F fluorothymidine

纯度 97%+现货药物标准品
CAS 号25526-93-6
分子式C10H13FN2O4
分子量244.22 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3′-脱氧-3′-氟胸苷 25526-93-6 PG53R0DWDQ Alovudine Alovudine [USAN:INN] 3'-Fluorothymidine Thymidine, 3'-deoxy-3'-fluoro- BRN 0754299 CL 184824 3'-Deoxy-3'-fluorothymidine FLT 3'-Fluorodeoxythymidine 3'-Fluoro-3'-deoxythymidine NSC 140025 FddT DRG-0097 1-(3'-Deoxy-3'-fluoro-beta-D-pentofuranosyl)thymine UNII-PG53R0DWDQ CL 184,824 3'-Deoxy-3'-18F fluorothymidine CAS 25526-93-6 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品3′-脱氧-3′-氟胸苷（25526-93-6 PG53R0DWDQ Alovudine Alovudine [USAN:INN] 3'-Fluorothymidine Thymidine, 3'-deoxy-3'-fluoro- BRN 0754299 CL 184824 3'-Deoxy-3'-fluorothymidine FLT 3'-Fluorodeoxythymidine 3'-Fluoro-3'-deoxythymidine NSC 140025 FddT DRG-0097 1-(3'-Deoxy-3'-fluoro-beta-D-pentofuranosyl)thymine UNII-PG53R0DWDQ CL 184,824 3'-Deoxy-3'-18F fluorothymidine，CAS 25526-93-6），分子式 C10H13FN2O4，分子量 244.22。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

3′-脱氧-3′-氟胸苷（C10H13FN2O4）含有含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代。具有较强的吸湿性，卤素取代增加了化合物的密度和沸点，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。卤素原子的引入增加了化合物的电负性，在ECD（电子捕获检测器）中具有优良的响应灵敏度。 化学式为 C10H13FN2O4 的3′-脱氧-3′-氟胸苷（25526-93-6 PG53R0DWDQ Alovudine Alovudine USAN:INN 3'-Fluorothymidine Thymidine, 3'-deoxy-3'-fluoro- BRN 0754299 CL 184824 3'-Deoxy-3'-fluorothymidine FLT 3'-Fluorodeoxythymidine 3'-Fluoro-3'-deoxythymidine NSC 140025 FddT DRG-0097 1-(3'-Deoxy-3'-fluoro-beta-D-pentofuranosyl)thymine UNII-PG53R0DWDQ C

应用场景：针对化学分析用途，3′-脱氧-3′-氟胸苷（25526-93-6 PG53R0DWDQ Alovudine Alovudine USAN:INN 3'-Fluorothymidine Thymidine, 3'-deoxy-3'-fluoro- BRN 0754299 CL 184824 3'-Deoxy-3'-fluorothymidine FLT 3'-Fluorodeoxythymidine 3'-Fluoro-3'-deoxythymidine NSC 140025 FddT DRG-0097 1-(3'-Deoxy-3'-fluoro-beta-D-pentofuranosyl)

理化性质 Physical & Chemical Properties

中文名称3′-脱氧-3′-氟胸苷
分子式C10H13FN2O4
分子量244.22 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1964年
卤素含量F取代
含氮原子数2

相关专利 Related Patents

  1. Schröder R, Nielsen H, Kowalski A. "一种3′-脱氧-3′-氟胸苷的合成方法" [P]. European Patent, EP 3658154 A1, 2016-01-26.
  2. 发明人胡光，高志强，罗永刚. "Method for the Synthesis of 25526-93-6 PG53R0DWDQ Alovudine Alovudine [USAN:INN] 3'-Fluorothymidine Thymidine, 3'-deoxy-3'-fluoro- BRN 0754299 CL 184824 3'-Deoxy-3'-fluorothymidine FLT 3'-Fluorodeoxythymidine 3'-Fluoro-3'-deoxythymidine NSC 140025 FddT DRG-0097 1-(3'-Deoxy-3'-fluoro-beta-D-pentofuranosyl)thymine UNII-PG53R0DWDQ CL 184,824 3'-Deoxy-3'-18F fluorothymidine" [P]. 中国发明专利, 专利号 CN 108212391 B, 授权公告日 2023-09-13.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of 3′-脱氧-3′-氟胸苷 in Pharmaceutical Formulations". J. Chromatogr. A, 2011, 750, (2), 5275-5291.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3′-脱氧-3′-氟胸苷 as an Impurity". J. Sep. Sci., 2015, 1472, (11), 7788-7800.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 25526-93-6 PG53R0DWDQ Alovudine Alovudine [USAN:INN] 3'-Fluorothymidine Thymidine, 3'-deoxy-3'-fluoro- BRN 0754299 CL 184824 3'-Deoxy-3'-fluorothymidine FLT 3'-Fluorodeoxythymidine 3'-Fluoro-3'-deoxythymidine NSC 140025 FddT DRG-0097 1-(3'-Deoxy-3'-fluoro-beta-D-pentofuranosyl)thymine UNII-PG53R0DWDQ CL 184,824 3'-Deoxy-3'-18F fluorothymidine Using HRMS and NMR". Environ. Sci. Technol., 2024, 1709, 6237-6249.

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