(Z)-4-((1S,3aR,5S,11R,14aS)-8-羟基-2,2,11-三甲基-13-(3-甲基丁-2-烯-1-基)-11-(4-甲基戊-3-烯-1-基)-4,7-二氧代-2,3a,4,5,7,11-六氢-1H-1,5-甲桥呋喃并[3,2-g]吡喃并[3,2-b]氧杂蒽-3a-基)-2-甲基丁-2-烯酰胺 CAS 286935-60-2

(Z)-4-((1S,3aR,5S,11R,14aS)-8-Hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydro-1H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a-yl)-2-methylbut-2-enamide

纯度 97%+现货药物标准品
CAS 号286935-60-2
分子式C38H45NO7
分子量627.77 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(Z)-4-((1S,3aR,5S,11R,14aS)-8-羟基-2,2,11-三甲基-13-(3-甲基丁-2-烯-1-基)-11-(4-甲基戊-3-烯-1-基)-4,7-二氧代-2,3a,4,5,7,11-六氢-1H-1,5-甲桥呋喃并[3,2-g]吡喃并[3,2-b]氧杂蒽-3a-基)-2-甲基丁-2-烯酰胺 (Z)-4-((1S,3aR,5S,11R,14aS)-8-Hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydro-1H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a-yl)-2-methylbut-2-enamide CAS 286935-60-2 结构式 Chemical Structure

产品介绍 Description

(Z)-4-((1S,3aR,5S,11R,14aS)-8-羟基-2,2,11-三甲基-13-(3-甲基丁-2-烯-1-基)-11-(4-甲基戊-3-烯-1-基)-4,7-二氧代-2,3a,4,5,7,11-六氢-1H-1,5-甲桥呋喃并[3,2-g]吡喃并[3,2-b]氧杂蒽-3a-基)-2-甲基丁-2-烯酰胺（(Z)-4-((1S,3aR,5S,11R,14aS)-8-Hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydro-1H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a-yl)-2-methylbut-2-enamide）是药物分析与质量控制领域常用的药物标准品，CAS 号 286935-60-2。分子式 C38H45NO7，分子量 627.77。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，(Z)-4-((1S,3aR,5S,11R,14aS)-8-羟基-2,2,11-三甲基-13-(3-甲基丁-2-烯-1-基)-11-(4-甲基戊-3-烯-1-基)-4,7-二氧代-2,3a,4,5,7,11-六氢-1H-1,5-甲桥呋喃并3,2-g吡喃并3,2-b氧杂蒽-3a-基)-2-甲基丁-2-烯酰胺的分子量为627.77 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 286935-60-2 对应的化合物(Z)-4-((1S,3aR,5S,11R,14aS)-8-羟基-2,2,11-三甲基-13-(3-甲基丁-2-烯-1-基)-11-(4-甲基戊-3-烯-1-基)-4,7-二氧代-2,3a,4,5,7,11-六氢-1H-1,5-甲桥呋喃并3,2-g吡喃并3,2-b氧杂蒽-3a-基)-2-甲基丁-2-烯酰胺（英文标识 (Z)-4-((1S,3aR,5S,11R,14aS)-8-Hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpen

应用场景：(Z)-4-((1S,3aR,5S,11R,14aS)-8-羟基-2,2,11-三甲基-13-(3-甲基丁-2-烯-1-基)-11-(4-甲基戊-3-烯-1-基)-4,7-二氧代-2,3a,4,5,7,11-六氢-1H-1,5-甲桥呋喃并 3,2-g 吡喃并 3,2-b 氧杂蒽-3a-基)-2-甲基丁-2-烯酰胺（(Z)-4-((1S,3aR,5S,11R,14aS)-8-Hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydr

理化性质 Physical & Chemical Properties

中文名称(Z)-4-((1S,3aR,5S,11R,14aS)-8-羟基-2,2,11-三甲基-13-(3-甲基丁-2-烯-1-基)-11-(4-甲基戊-3-烯-1-基)-4,7-二氧代-2,3a,4,5,7,11-六氢-1H-1,5-甲桥呋喃并[3,2-g]吡喃并[3,2-b]氧杂蒽-3a-基)-2-甲基丁-2-烯酰胺
分子式C38H45NO7
分子量627.77 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）17.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
含氮原子数1

相关专利 Related Patents

  1. 发明人马晓峰，王建平，周伟. "一种(Z)-4-((1S,3aR,5S,11R,14aS)-8-羟基-2,2,11-三甲基-13-(3-甲基丁-2-烯-1-基)-11-(4-甲基戊-3-烯-1-基)-4,7-二氧代-2,3a,4,5,7,11-六氢-1H-1,5-甲桥呋喃并[3,2-g]吡喃并[3,2-b]氧杂蒽-3a-基)-2-甲基丁-2-烯酰胺的合成方法" [P]. 中国发明专利, 专利号 CN 110824641 A, 授权公告日 2018-12-04.
  2. Brown S R, Yamamoto T, Stevens L M. "Method for the Synthesis of (Z)-4-((1S,3aR,5S,11R,14aS)-8-Hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydro-1H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a-yl)-2-methylbut-2-enamide" [P]. US Patent, US 9740096 B2, 2025-01-03.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of (Z)-4-((1S,3aR,5S,11R,14aS)-8-羟基-2,2,11-三甲基-13-(3-甲基丁-2-烯-1-基)-11-(4-甲基戊-3-烯-1-基)-4,7-二氧代-2,3a,4,5,7,11-六氢-1H-1,5-甲桥呋喃并[3,2-g]吡喃并[3,2-b]氧杂蒽-3a-基)-2-甲基丁-2-烯酰胺 in Pharmaceutical Formulations". Anal. Chem., 2014, 737, (12), 1682-1685.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of (Z)-4-((1S,3aR,5S,11R,14aS)-8-羟基-2,2,11-三甲基-13-(3-甲基丁-2-烯-1-基)-11-(4-甲基戊-3-烯-1-基)-4,7-二氧代-2,3a,4,5,7,11-六氢-1H-1,5-甲桥呋喃并[3,2-g]吡喃并[3,2-b]氧杂蒽-3a-基)-2-甲基丁-2-烯酰胺 as an Impurity". Food Chem., 2022, 509, 3350-3372.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of (Z)-4-((1S,3aR,5S,11R,14aS)-8-Hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydro-1H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a-yl)-2-methylbut-2-enamide Using HRMS and NMR". Phytochemistry, 2024, 98, 903-918.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate (Z)-4-((1S,3aR,5S,11R,14aS)-8-羟基-2,2,11-三甲基-13-(3-甲基丁-2-烯-1-基)-11-(4-甲基戊-3-烯-1-基)-4,7-二氧代-2,3a,4,5,7,11-六氢-1H-1,5-甲桥呋喃并[3,2-g]吡喃并[3,2-b]氧杂蒽-3a-基)-2-甲基丁-2-烯酰胺 Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2016, 706, (6), 2191-2216.

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