3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene CAS 294193-86-5

3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene

纯度 97%+现货药物标准品
CAS 号294193-86-5
分子式C19H17N5S
分子量347.44 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene 3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene CAS 294193-86-5 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene（3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene，CAS 294193-86-5），分子式 C19H17N5S，分子量 347.44。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

化学式为 C19H17N5S 的3-2-(1H-indol-3-ylmethylidene)hydrazin-1-yl-8-thia-4,6-diazatricyclo7.4.0.0^{2,7}trideca-1(9),2(7),3,5-tetraene（3-2-(1H-indol-3-ylmethylidene)hydrazin-1-yl-8-thia-4,6-diazatricyclo7.4.0.0^{2,7}trideca-1(9),2(7),3,5-tetraene），其CAS登记号是 294193-86-5，分子量为 347.44 g/mol。 3-2-(1H-indol-3-ylmethylidene)hydrazin-1-yl-8-thia-4,6-diazatricyclo7.4.0.0^{2,7}trideca-1(9),2(7),3,5-tetraene（分子式 C19H17N5S）的化学结构中包含含氮杂环结构，含氰基，含硫有机。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提

应用场景：3- 2-(1H-indol-3-ylmethylidene)hydrazin-1-yl -8-thia-4,6-diazatricyclo 7.4.0.0^{2,7} trideca-1(9),2(7),3,5-tetraene（3- 2-(1H-indol-3-ylmethylidene)hydrazin-1-yl -8-thia-4,6-diazatricyclo 7.4.0.0^{2,7} trideca-1(9),2(7),3,5-tetraene，CAS 294193-86-5）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以3- 2-(1H-indol-3-ylmeth

理化性质 Physical & Chemical Properties

中文名称3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene
分子式C19H17N5S
分子量347.44 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）14.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
含氮原子数5
含硫原子数1

相关专利 Related Patents

  1. Nowak P, Nielsen H, Kowalski A. "一种3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene的合成方法" [P]. European Patent, EP 3592310 A1, 2015-12-20.
  2. 发明人周伟，何建平，冯建国. "Method for the Synthesis of 3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene" [P]. 中国发明专利, 专利号 CN 115731084 B, 授权公告日 2019-09-18.
  3. 发明人韩伟，刘建华，胡光. "A Process for Preparing High-Purity 3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene" [P]. 中国发明专利, 专利号 CN 113238450 A, 授权公告日 2021-11-02.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of 3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene in Pharmaceutical Formulations". Chemosphere, 2013, 2454, 3433-3448.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene as an Impurity". Anal. Chem., 2024, 2446, 5122-5142.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene Using HRMS and NMR". Food Chem., 2017, 267, 9015-9041.
  4. Kim S H, Park J Y. "Forced Degradation Studies to Evaluate 3-[2-(1H-indol-3-ylmethylidene)hydrazin-1-yl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraene Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2022, 98, (7), 9367-9391.

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