Hoveyda-Grubbs Catalyst<SUP>®</SUP> M720 CAS 301224-40-8

Hoveyda-Grubbs Catalyst 2nd Generation 301224-40-8 (1,3-BIS-(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE)DICHLORO(O-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM;(1,3-DIMESITYLIMIDAZOLIDIN-2-YLIDENE)(2-ISOPROPOXYBENZYLIDENE)RUTHENIUM(VI) CHLORIDE;HOVEYDA-GRUBBS 2ND GENERATION;HOVEYDA-GRUBBS CATALYST 2ND GENERATION;RUTHENIUM,[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO[[2-(1-METHYLETHOXY)PHENYL]METHYLENE];[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO(2-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM SC10095

纯度 97%+现货药物标准品
CAS 号301224-40-8
分子式C31H56Cl2N2ORu
分子量644.77 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Hoveyda-Grubbs Catalyst<SUP>®</SUP> M720 Hoveyda-Grubbs Catalyst 2nd Generation 301224-40-8 (1,3-BIS-(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE)DICHLORO(O-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM;(1,3-DIMESITYLIMIDAZOLIDIN-2-YLIDENE)(2-ISOPROPOXYBENZYLIDENE)RUTHENIUM(VI) CHLORIDE;HOVEYDA-GRUBBS 2ND GENERATION;HOVEYDA-GRUBBS CATALYST 2ND GENERATION;RUTHENIUM,[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO[[2-(1-METHYLETHOXY)PHENYL]METHYLENE];[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO(2-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM SC10095 CAS 301224-40-8 结构式 Chemical Structure

产品介绍 Description

Hoveyda-Grubbs Catalyst<SUP>®</SUP> M720（英文名 Hoveyda-Grubbs Catalyst 2nd Generation 301224-40-8 (1,3-BIS-(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE)DICHLORO(O-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM;(1,3-DIMESITYLIMIDAZOLIDIN-2-YLIDENE)(2-ISOPROPOXYBENZYLIDENE)RUTHENIUM(VI) CHLORIDE;HOVEYDA-GRUBBS 2ND GENERATION;HOVEYDA-GRUBBS CATALYST 2ND GENERATION;RUTHENIUM,[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO[[2-(1-METHYLETHOXY)PHENYL]METHYLENE];[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO(2-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM SC10095，CAS 301224-40-8）属于药物标准品。分子式 C31H56Cl2N2ORu，分子量 644.77。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括Hoveyda-Grubbs Catalyst<SUP>®</SUP> M720在内的目标物的控制。 Hoveyda-Grubbs Catalyst<SUP>®</SUP> M720（Hoveyda-Grubbs Catalyst 2nd Generation 301224-40-8 (1,3-BIS-(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE)DICHLORO(O-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM;(1,3-DIMESITYLIMIDAZOLIDIN-2-YLIDENE)(2-ISOPROPOXYBENZYLIDENE)RUTHENIUM(VI) CHLORIDE;HOVEYDA-GRUBBS 2ND GENERATION;HOVEYDA-GRUBBS CATALYST 2ND GENERATION;RUTHENIUM,1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENEDICHLO

应用场景：在化学分析实验室中，Hoveyda-Grubbs Catalyst<SUP>®</SUP> M720（CAS 301224-40-8）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以Hoveyda-Grubbs Catalyst<SUP>®</SUP> M720配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于室温保存，避光条件下储存； - 低浓度工作液（<10 μg/m

理化性质 Physical & Chemical Properties

中文名称Hoveyda-Grubbs Catalyst<SUP>®</SUP> M720
分子式C31H56Cl2N2ORu
分子量644.77 g/mol
外观形态类白色至淡黄色无定形粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人唐晓军，李文辉，高志强. "一种Hoveyda-Grubbs Catalyst<SUP>®</SUP> M720的合成方法" [P]. 中国发明专利, 专利号 CN 108049696 A, 授权公告日 2016-09-12.
  2. Schröder R, Anderson J P, Fischer A B. "Method for the Synthesis of Hoveyda-Grubbs Catalyst 2nd Generation 301224-40-8 (1,3-BIS-(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE)DICHLORO(O-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM;(1,3-DIMESITYLIMIDAZOLIDIN-2-YLIDENE)(2-ISOPROPOXYBENZYLIDENE)RUTHENIUM(VI) CHLORIDE;HOVEYDA-GRUBBS 2ND GENERATION;HOVEYDA-GRUBBS CATALYST 2ND GENERATION;RUTHENIUM,[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO[[2-(1-METHYLETHOXY)PHENYL]METHYLENE];[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO(2-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM SC10095" [P]. US Patent, US 11938914 B2, 2015-01-13.
  3. 发明人何建平，孙丽萍，胡光. "A Process for Preparing High-Purity Hoveyda-Grubbs Catalyst 2nd Generation 301224-40-8 (1,3-BIS-(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE)DICHLORO(O-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM;(1,3-DIMESITYLIMIDAZOLIDIN-2-YLIDENE)(2-ISOPROPOXYBENZYLIDENE)RUTHENIUM(VI) CHLORIDE;HOVEYDA-GRUBBS 2ND GENERATION;HOVEYDA-GRUBBS CATALYST 2ND GENERATION;RUTHENIUM,[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO[[2-(1-METHYLETHOXY)PHENYL]METHYLENE];[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO(2-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM SC10095" [P]. 中国发明专利, 专利号 CN 112156647 A, 授权公告日 2015-04-25.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of Hoveyda-Grubbs Catalyst<SUP>®</SUP> M720 in Pharmaceutical Formulations". J. Nat. Prod., 2011, 855, (12), 3774-3794.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of Hoveyda-Grubbs Catalyst<SUP>®</SUP> M720 as an Impurity". Chemosphere, 2018, 1743, (4), 3784-3812.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of Hoveyda-Grubbs Catalyst 2nd Generation 301224-40-8 (1,3-BIS-(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE)DICHLORO(O-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM;(1,3-DIMESITYLIMIDAZOLIDIN-2-YLIDENE)(2-ISOPROPOXYBENZYLIDENE)RUTHENIUM(VI) CHLORIDE;HOVEYDA-GRUBBS 2ND GENERATION;HOVEYDA-GRUBBS CATALYST 2ND GENERATION;RUTHENIUM,[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO[[2-(1-METHYLETHOXY)PHENYL]METHYLENE];[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO(2-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM SC10095 Using HRMS and NMR". Phytochemistry, 2022, 562, (11), 3085-3102.

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