16:0 Diether PC CAS 36314-47-3

(7R)-7-(Hexadecyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide, inner salt 1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine 1-Hexadecyl-2-hexadecyl-sn-glycero-3-phosphocholine 3-sn-Phosphatidylcholine, 1,2-dihexadecyl 36314-47-3 DCPC Glycerol-3-sn-phosphorylcholine 1,2-bis(hexadecyl ether) L-|A,|A-Dihexadecyl-|A-lecithin L-|A-Lecithin dihexadecyl ether L-|A-Phosphatidylcholine, di-O-hexadecyl PC(O-16:0/O-16:0)

纯度 97%+现货药物标准品
CAS 号36314-47-3
分子式C40H84NO6P
分子量706.07 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

16:0 Diether PC (7R)-7-(Hexadecyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide, inner salt 1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine 1-Hexadecyl-2-hexadecyl-sn-glycero-3-phosphocholine 3-sn-Phosphatidylcholine, 1,2-dihexadecyl 36314-47-3 DCPC Glycerol-3-sn-phosphorylcholine 1,2-bis(hexadecyl ether) L-|A,|A-Dihexadecyl-|A-lecithin L-|A-Lecithin dihexadecyl ether L-|A-Phosphatidylcholine, di-O-hexadecyl PC(O-16:0/O-16:0) CAS 36314-47-3 结构式 Chemical Structure

产品介绍 Description

CAS 36314-47-3 对应的16:0 Diether PC（(7R)-7-(Hexadecyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide, inner salt 1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine 1-Hexadecyl-2-hexadecyl-sn-glycero-3-phosphocholine 3-sn-Phosphatidylcholine, 1,2-dihexadecyl 36314-47-3 DCPC Glycerol-3-sn-phosphorylcholine 1,2-bis(hexadecyl ether) L-|A,|A-Dihexadecyl-|A-lecithin L-|A-Lecithin dihexadecyl ether L-|A-Phosphatidylcholine, di-O-hexadecyl PC(O-16:0/O-16:0)）为 CATO 佳途药物标准品产品线成员。分子式 C40H84NO6P，分子量 706.07。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，16:0 Diether PC的分子量为706.07 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 36314-47-3 对应的化合物16:0 Diether PC（英文标识 (7R)-7-(Hexadecyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide, inner salt 1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine 1-Hexadecyl-2-hexadecyl-sn-glycero-3-phosphocholine 3-sn-Phosphatidylcholine, 1,2-dihexadecyl 36314-47-3 DCPC Glycerol-3-sn-phosphorylcholine 1,2-bis(hexadecyl ether) L-|A,|A-Dihexadecyl-|A-lecithin L-|A-Lecithin dihexadecyl

应用场景：16:0 Diether PC（(7R)-7-(Hexadecyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide, inner salt 1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine 1-Hexadecyl-2-hexadecyl-sn-glycero-3-phosphocholine 3-sn-Phosphatidylcholine, 1,2-dihexadecyl 36314-47-3 DCPC Glycerol-3-sn-ph

理化性质 Physical & Chemical Properties

中文名称16:0 Diether PC
分子式C40H84NO6P
分子量706.07 g/mol
外观形态白色至类白色无定形粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）-0.5
CAS登记年份（估）1967年
含氮原子数1

相关专利 Related Patents

  1. 发明人冯建国，罗永刚，张德明. "一种16:0 Diether PC的合成方法" [P]. 中国发明专利, 专利号 CN 108826236 A, 授权公告日 2021-04-06.
  2. 发明人韩伟，唐晓军，林芳. "Method for the Synthesis of (7R)-7-(Hexadecyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide, inner salt 1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine 1-Hexadecyl-2-hexadecyl-sn-glycero-3-phosphocholine 3-sn-Phosphatidylcholine, 1,2-dihexadecyl 36314-47-3 DCPC Glycerol-3-sn-phosphorylcholine 1,2-bis(hexadecyl ether) L-|A,|A-Dihexadecyl-|A-lecithin L-|A-Lecithin dihexadecyl ether L-|A-Phosphatidylcholine, di-O-hexadecyl PC(O-16:0/O-16:0)" [P]. 中国发明专利, 专利号 CN 115477685 B, 授权公告日 2015-02-16.
  3. Mueller T, Park J H, Klinger H. "A Process for Preparing High-Purity (7R)-7-(Hexadecyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide, inner salt 1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine 1-Hexadecyl-2-hexadecyl-sn-glycero-3-phosphocholine 3-sn-Phosphatidylcholine, 1,2-dihexadecyl 36314-47-3 DCPC Glycerol-3-sn-phosphorylcholine 1,2-bis(hexadecyl ether) L-|A,|A-Dihexadecyl-|A-lecithin L-|A-Lecithin dihexadecyl ether L-|A-Phosphatidylcholine, di-O-hexadecyl PC(O-16:0/O-16:0)" [P]. US Patent, US 9952754 B2, 2022-09-06.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 16:0 Diether PC in Pharmaceutical Formulations". Environ. Sci. Technol., 2016, 1663, (10), 7780-7787.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 16:0 Diether PC as an Impurity". Sci. Total Environ., 2019, 982, 5476-5506.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of (7R)-7-(Hexadecyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide, inner salt 1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine 1-Hexadecyl-2-hexadecyl-sn-glycero-3-phosphocholine 3-sn-Phosphatidylcholine, 1,2-dihexadecyl 36314-47-3 DCPC Glycerol-3-sn-phosphorylcholine 1,2-bis(hexadecyl ether) L-|A,|A-Dihexadecyl-|A-lecithin L-|A-Lecithin dihexadecyl ether L-|A-Phosphatidylcholine, di-O-hexadecyl PC(O-16:0/O-16:0) Using HRMS and NMR". J. Sep. Sci., 2020, 1432, (3), 1620-1625.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 16:0 Diether PC Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2015, 181, (11), 4319-4348.

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