C16-20:4 PC CAS 86288-11-1

(2R)-3-(hexadecyloxy)-2-{[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphate 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine 1-O-hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine 86288-11-1 CHEBI:55430 PC(O-16:0/20:4(5Z,8Z,11Z,14Z))

纯度 97%+现货药物标准品
CAS 号86288-11-1
分子式C44H82NO7P
分子量768.10 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

C16-20:4 PC (2R)-3-(hexadecyloxy)-2-{[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphate 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine 1-O-hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine 86288-11-1 CHEBI:55430 PC(O-16:0/20:4(5Z,8Z,11Z,14Z)) CAS 86288-11-1 结构式 Chemical Structure

产品介绍 Description

CAS 86288-11-1 对应的C16-20:4 PC（(2R)-3-(hexadecyloxy)-2-{[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphate 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine 1-O-hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine 86288-11-1 CHEBI:55430 PC(O-16:0/20:4(5Z,8Z,11Z,14Z))）为 CATO 佳途药物标准品产品线成员。分子式 C44H82NO7P，分子量 768.10。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

CAS编号 86288-11-1 对应的化合物C16-20:4 PC（英文标识 (2R)-3-(hexadecyloxy)-2-{(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy}propyl 2-(trimethylazaniumyl)ethyl phosphate 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine 1-O-hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine 86288-11-1 CHEBI:55430 PC(O-16:0/20:4(5Z,8Z,11Z,14Z))），化学式 C44H82NO7P，相对分子质量 768.10。 C16-20:4 PC（分子式 C44H82NO7P）的化学结构中包含含氮杂环结构，酰胺类，含磷酸酯基，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。

应用场景：C16-20:4 PC（(2R)-3-(hexadecyloxy)-2-{ (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl oxy}propyl 2-(trimethylazaniumyl)ethyl phosphate 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine 1-O-hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine 86288-11-1 CHEBI:55430 PC(O-16:0/20:4

理化性质 Physical & Chemical Properties

中文名称C16-20:4 PC
分子式C44H82NO7P
分子量768.10 g/mol
外观形态类白色至淡黄色无定形粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1981年
含氮原子数1

相关专利 Related Patents

  1. 发明人林芳，陈志强，周伟. "一种C16-20:4 PC的合成方法" [P]. 中国发明专利, 专利号 CN 109837697 B, 授权公告日 2017-06-14.
  2. Fischer A B, Stevens L M, Schröder R. "Method for the Synthesis of (2R)-3-(hexadecyloxy)-2-{[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphate 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine 1-O-hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine 86288-11-1 CHEBI:55430 PC(O-16:0/20:4(5Z,8Z,11Z,14Z))" [P]. US Patent, US 11816883 B2, 2023-06-13.
  3. 发明人唐晓军，沈红梅，黄志刚. "A Process for Preparing High-Purity (2R)-3-(hexadecyloxy)-2-{[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphate 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine 1-O-hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine 86288-11-1 CHEBI:55430 PC(O-16:0/20:4(5Z,8Z,11Z,14Z))" [P]. 中国发明专利, 专利号 CN 116477577 A, 授权公告日 2024-04-10.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of C16-20:4 PC in Pharmaceutical Formulations". Talanta, 2023, 2061, (11), 5070-5083.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of C16-20:4 PC as an Impurity". Food Chem., 2019, 2403, (8), 3934-3947.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of (2R)-3-(hexadecyloxy)-2-{[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphate 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine 1-O-hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine 86288-11-1 CHEBI:55430 PC(O-16:0/20:4(5Z,8Z,11Z,14Z)) Using HRMS and NMR". Phytochemistry, 2012, 1703, 8620-8629.

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