(<I>R</I>)-(+)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶 CAS 442905-33-1

442905-33-1 N2PCW56063 Xyl-p-phos, (R)- UNII-N2PCW56063 (R)-Xyl-p-phos [MI] 3,3'-Bipyridine, 4,4'-bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-, (3R)- (R)-(+)-2,2,6,6-Tetramethoxy-4,4-bis(di(3,5-xylyl)phosphino)-3,3-bipyridine P-PHOS Ligands, (R)-xyl-p-phos-

纯度 97%+现货药物标准品
CAS 号442905-33-1
分子式C46H86N2O4P2
分子量793.13 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>R</I>)-(+)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶 442905-33-1 N2PCW56063 Xyl-p-phos, (R)- UNII-N2PCW56063 (R)-Xyl-p-phos [MI] 3,3'-Bipyridine, 4,4'-bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-, (3R)- (R)-(+)-2,2,6,6-Tetramethoxy-4,4-bis(di(3,5-xylyl)phosphino)-3,3-bipyridine P-PHOS Ligands, (R)-xyl-p-phos- CAS 442905-33-1 结构式 Chemical Structure

产品介绍 Description

(<I>R</I>)-(+)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶（英文名 442905-33-1 N2PCW56063 Xyl-p-phos, (R)- UNII-N2PCW56063 (R)-Xyl-p-phos [MI] 3,3'-Bipyridine, 4,4'-bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-, (3R)- (R)-(+)-2,2,6,6-Tetramethoxy-4,4-bis(di(3,5-xylyl)phosphino)-3,3-bipyridine P-PHOS Ligands, (R)-xyl-p-phos-，CAS 442905-33-1）属于药物标准品。分子式 C46H86N2O4P2，分子量 793.13。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括(<I>R</I>)-(+)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶在内的目标物的控制。 (<I>R</I>)-(+)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶（442905-33-1 N2PCW56063 Xyl-p-phos, (R)- UNII-N2PCW56063 (R)-Xyl-p-phos MI 3,3'-Bipyridine, 4,4'-bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-, (3R)- (R)-(+)-2,2,6,6-Tetramethoxy-4,4-bis(di(3,5-xylyl)phosphino)-3,3-bipyridine P-PHOS Ligands, (R)-xyl-p-phos-），CAS注册编号 442905-33-1，化学分子式为 C46H86N2O4P2，分子量 793.13 g/mol。 从化学结构特

应用场景：针对化学分析用途，(<I>R</I>)-(+)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶（442905-33-1 N2PCW56063 Xyl-p-phos, (R)- UNII-N2PCW56063 (R)-Xyl-p-phos MI 3,3'-Bipyridine, 4,4'-bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-, (3R)- (R)-(+)-2,2,6,6-Tetramethoxy-4,4-bis(di(3,5-xylyl)phosphino)-3,3-

理化性质 Physical & Chemical Properties

中文名称(<I>R</I>)-(+)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶
分子式C46H86N2O4P2
分子量793.13 g/mol
外观形态类白色至淡黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
含氮原子数2

相关专利 Related Patents

  1. 发明人钱学锋，郑宇鹏，郭海燕. "一种(<I>R</I>)-(+)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶的合成方法" [P]. 中国发明专利, 专利号 CN 117058367 B, 授权公告日 2017-01-17.
  2. 发明人杨光，韩伟，胡光. "Method for the Synthesis of 442905-33-1 N2PCW56063 Xyl-p-phos, (R)- UNII-N2PCW56063 (R)-Xyl-p-phos [MI] 3,3'-Bipyridine, 4,4'-bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-, (3R)- (R)-(+)-2,2,6,6-Tetramethoxy-4,4-bis(di(3,5-xylyl)phosphino)-3,3-bipyridine P-PHOS Ligands, (R)-xyl-p-phos-" [P]. 中国发明专利, 专利号 CN 110818203 A, 授权公告日 2023-07-17.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>R</I>)-(+)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶 in Pharmaceutical Formulations". Biomed. Chromatogr., 2018, 99, 5579-5602.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>R</I>)-(+)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶 as an Impurity". Anal. Chem., 2016, 1715, (12), 1763-1788.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 442905-33-1 N2PCW56063 Xyl-p-phos, (R)- UNII-N2PCW56063 (R)-Xyl-p-phos [MI] 3,3'-Bipyridine, 4,4'-bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-, (3R)- (R)-(+)-2,2,6,6-Tetramethoxy-4,4-bis(di(3,5-xylyl)phosphino)-3,3-bipyridine P-PHOS Ligands, (R)-xyl-p-phos- Using HRMS and NMR". Anal. Methods, 2011, 352, (9), 7902-7921.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate (<I>R</I>)-(+)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶 Profile in Drug Substances According to ICH Guidelines". Talanta, 2016, 1002, (12), 8715-8741.

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