(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶 CAS 443347-10-2

443347-10-2 1A4EO1493Y Xyl-p-phos, (S)- UNII-1A4EO1493Y (S)-Xyl-p-phos [MI] 3,3'-Bipyridine, 4,4'-bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-, (3S)- (S)-(-)-2,2,6,6-Tetramethoxy-4,4-bis(di(3,5-xylyl)phosphino)-3,3-bipyridine P-PHOS Ligands, (S)-xyl-p-phos-

纯度 97%+现货药物标准品
CAS 号443347-10-2
分子式C46H86N2O4P2
分子量793.13 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶 443347-10-2 1A4EO1493Y Xyl-p-phos, (S)- UNII-1A4EO1493Y (S)-Xyl-p-phos [MI] 3,3'-Bipyridine, 4,4'-bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-, (3S)- (S)-(-)-2,2,6,6-Tetramethoxy-4,4-bis(di(3,5-xylyl)phosphino)-3,3-bipyridine P-PHOS Ligands, (S)-xyl-p-phos- CAS 443347-10-2 结构式 Chemical Structure

产品介绍 Description

(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶（443347-10-2 1A4EO1493Y Xyl-p-phos, (S)- UNII-1A4EO1493Y (S)-Xyl-p-phos [MI] 3,3'-Bipyridine, 4,4'-bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-, (3S)- (S)-(-)-2,2,6,6-Tetramethoxy-4,4-bis(di(3,5-xylyl)phosphino)-3,3-bipyridine P-PHOS Ligands, (S)-xyl-p-phos-）是药物分析与质量控制领域常用的药物标准品，CAS 号 443347-10-2。分子式 C46H86N2O4P2，分子量 793.13。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶的分子量为793.13 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C46H86N2O4P2 的(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶（443347-10-2 1A4EO1493Y Xyl-p-phos, (S)- UNII-1A4EO1493Y (S)-Xyl-p-phos MI 3,3'-Bipyridine, 4,4'-bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-, (3S)- (S)-(-)-2,2,6,6-Tetramethoxy-4,4-bis(di(3,5-xylyl)phosphino)-3,3-bipyridine P-PHOS Ligands, (S)-xyl-p-phos-），其CAS登记号是 443347-10-2，分子量为 793

应用场景：在化学分析实验室中，(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶（CAS 443347-10-2）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶
分子式C46H86N2O4P2
分子量793.13 g/mol
外观形态类白色至淡黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
含氮原子数2

相关专利 Related Patents

  1. Johnson M A, O'Brien P Q, Lee S K. "一种(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶的合成方法" [P]. US Patent, US 11058522 B2, 2022-08-23.
  2. 发明人王建平，陈志强，朱建伟. "Method for the Synthesis of 443347-10-2 1A4EO1493Y Xyl-p-phos, (S)- UNII-1A4EO1493Y (S)-Xyl-p-phos [MI] 3,3'-Bipyridine, 4,4'-bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-, (3S)- (S)-(-)-2,2,6,6-Tetramethoxy-4,4-bis(di(3,5-xylyl)phosphino)-3,3-bipyridine P-PHOS Ligands, (S)-xyl-p-phos-" [P]. 中国发明专利, 专利号 CN 113547778 A, 授权公告日 2017-04-26.
  3. Jørgensen K, Martínez F, Mueller T C. "A Process for Preparing High-Purity 443347-10-2 1A4EO1493Y Xyl-p-phos, (S)- UNII-1A4EO1493Y (S)-Xyl-p-phos [MI] 3,3'-Bipyridine, 4,4'-bis(bis(3,5-dimethylphenyl)phosphino)-2,2',6,6'-tetramethoxy-, (3S)- (S)-(-)-2,2,6,6-Tetramethoxy-4,4-bis(di(3,5-xylyl)phosphino)-3,3-bipyridine P-PHOS Ligands, (S)-xyl-p-phos-" [P]. European Patent, EP 3079487 A1, 2025-12-04.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶 in Pharmaceutical Formulations". Phytochemistry, 2017, 1131, (12), 6589-6606.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二(3,5-二甲苯基)膦-3,3′-联吡啶 as an Impurity". Anal. Chim. Acta, 2020, 873, 5853-5872.

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