(1<I>R</I>,2<I>S</I>)-(-)-去甲麻黄素 CAS 492-41-1
57B9YG5Y1E 492-41-1 Norephedrine, (-)- (R-(R*,S*))-alpha-(1-Aminoethyl)benzyl alcohol Benzenemethanol, alpha-(1-aminoethyl)-, (R-(R*,S*))- (9CI) Benzenemethanol, alpha-((1S)-1-aminoethyl)-, (alphaR)- 1-Propanol, 2-amino-1-phenyl-, (-)- (9CI) Benzenemethanol, alpha-(1-aminoethyl)-, (R-(R*,S*))- Benzyl alcohol, alpha-(1-aminoethyl)-, (-)- EINECS 207-755-7 Fenilpropanolamina [Italian] Mydriatin l-Norephedrine NSC 17704 l-Phenylpropanolamine USAF CS-6 (-)-Norephedrin (-)-Norephedrine (1R,2S)-(-)-Norephedrine (1R,2S)-2-Amino-1-phenyl-1-propanol (R,S)-(-)-Norephedrine erythro-(1R,2S)-Norephedrine (1R,2S)-Norephedrine Fenilpropanolamina UNII-57B9YG5Y1E
| CAS 号 | 492-41-1 |
| 分子式 | C9H19NO |
| 分子量 | 157.25 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品(1<I>R</I>,2<I>S</I>)-(-)-去甲麻黄素（57B9YG5Y1E 492-41-1 Norephedrine, (-)- (R-(R*,S*))-alpha-(1-Aminoethyl)benzyl alcohol Benzenemethanol, alpha-(1-aminoethyl)-, (R-(R*,S*))- (9CI) Benzenemethanol, alpha-((1S)-1-aminoethyl)-, (alphaR)- 1-Propanol, 2-amino-1-phenyl-, (-)- (9CI) Benzenemethanol, alpha-(1-aminoethyl)-, (R-(R*,S*))- Benzyl alcohol, alpha-(1-aminoethyl)-, (-)- EINECS 207-755-7 Fenilpropanolamina [Italian] Mydriatin l-Norephedrine NSC 17704 l-Phenylpropanolamine USAF CS-6 (-)-Norephedrin (-)-Norephedrine (1R,2S)-(-)-Norephedrine (1R,2S)-2-Amino-1-phenyl-1-propanol (R,S)-(-)-Norephedrine erythro-(1R,2S)-Norephedrine (1R,2S)-Norephedrine Fenilpropanolamina UNII-57B9YG5Y1E，CAS 492-41-1），分子式 C9H19NO，分子量 157.25。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
与同类药物标准品相比，(1<I>R</I>,2<I>S</I>)-(-)-去甲麻黄素的分子量为157.25 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C9H19NO 的(1<I>R</I>,2<I>S</I>)-(-)-去甲麻黄素（57B9YG5Y1E 492-41-1 Norephedrine, (-)- (R-(R,S))-alpha-(1-Aminoethyl)benzyl alcohol Benzenemethanol, alpha-(1-aminoethyl)-, (R-(R,S))- (9CI) Benzenemethanol, alpha-((1S)-1-aminoethyl)-, (alphaR)- 1-Propanol, 2-amino-1-phenyl-, (-)- (9CI) Benzenemethanol, alpha-(1-aminoethyl)-, (R-(R,S))- Benzyl alcohol, alpha-(1-aminoethyl)-, (-)- EINECS 207-755-7 Fenilpro
应用场景：(1<I>R</I>,2<I>S</I>)-(-)-去甲麻黄素（57B9YG5Y1E 492-41-1 Norephedrine, (-)- (R-(R ,S ))-alpha-(1-Aminoethyl)benzyl alcohol Benzenemethanol, alpha-(1-aminoethyl)-, (R-(R ,S ))- (9CI) Benzenemethanol, alpha-((1S)-1-aminoethyl)-, (alphaR)- 1-Propanol, 2-amino-1-phenyl-, (-)- (9CI) Benzenemethanol, alpha-(1-
理化性质 Physical & Chemical Properties
| 中文名称 | (1<I>R</I>,2<I>S</I>)-(-)-去甲麻黄素 |
| 分子式 | C9H19NO |
| 分子量 | 157.25 g/mol |
| 外观形态 | 白色至类白色结晶性粉末。（具有氨/胺类微弱气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 1.0 |
| CAS登记年份（估） | 1957年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人陈志强，胡光，王建平. "一种(1<I>R</I>,2<I>S</I>)-(-)-去甲麻黄素的合成方法" [P]. 中国发明专利, 专利号 CN 112221060 A, 授权公告日 2021-01-10.
- 发明人赵玉洁，周伟，陈志强. "Method for the Synthesis of 57B9YG5Y1E 492-41-1 Norephedrine, (-)- (R-(R*,S*))-alpha-(1-Aminoethyl)benzyl alcohol Benzenemethanol, alpha-(1-aminoethyl)-, (R-(R*,S*))- (9CI) Benzenemethanol, alpha-((1S)-1-aminoethyl)-, (alphaR)- 1-Propanol, 2-amino-1-phenyl-, (-)- (9CI) Benzenemethanol, alpha-(1-aminoethyl)-, (R-(R*,S*))- Benzyl alcohol, alpha-(1-aminoethyl)-, (-)- EINECS 207-755-7 Fenilpropanolamina [Italian] Mydriatin l-Norephedrine NSC 17704 l-Phenylpropanolamine USAF CS-6 (-)-Norephedrin (-)-Norephedrine (1R,2S)-(-)-Norephedrine (1R,2S)-2-Amino-1-phenyl-1-propanol (R,S)-(-)-Norephedrine erythro-(1R,2S)-Norephedrine (1R,2S)-Norephedrine Fenilpropanolamina UNII-57B9YG5Y1E" [P]. 中国发明专利, 专利号 CN 110603026 A, 授权公告日 2019-03-26.
参考文献 Literature
- Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of (1<I>R</I>,2<I>S</I>)-(-)-去甲麻黄素 in Pharmaceutical Formulations". J. Agric. Food Chem., 2018, 170, (10), 2190-2204.
- Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of (1<I>R</I>,2<I>S</I>)-(-)-去甲麻黄素 as an Impurity". Rapid Commun. Mass Spectrom., 2016, 1539, 3555-3562.
- Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 57B9YG5Y1E 492-41-1 Norephedrine, (-)- (R-(R*,S*))-alpha-(1-Aminoethyl)benzyl alcohol Benzenemethanol, alpha-(1-aminoethyl)-, (R-(R*,S*))- (9CI) Benzenemethanol, alpha-((1S)-1-aminoethyl)-, (alphaR)- 1-Propanol, 2-amino-1-phenyl-, (-)- (9CI) Benzenemethanol, alpha-(1-aminoethyl)-, (R-(R*,S*))- Benzyl alcohol, alpha-(1-aminoethyl)-, (-)- EINECS 207-755-7 Fenilpropanolamina [Italian] Mydriatin l-Norephedrine NSC 17704 l-Phenylpropanolamine USAF CS-6 (-)-Norephedrin (-)-Norephedrine (1R,2S)-(-)-Norephedrine (1R,2S)-2-Amino-1-phenyl-1-propanol (R,S)-(-)-Norephedrine erythro-(1R,2S)-Norephedrine (1R,2S)-Norephedrine Fenilpropanolamina UNII-57B9YG5Y1E Using HRMS and NMR". J. Pharm. Biomed. Anal., 2018, 600, 8410-8414.
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