6-(4-叔丁氧羰基哌嗪-1-基)吡啶-3-硼酸频哪醇酯 CAS 496786-98-2

4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl -piperazine-1-carboxylic acid tert-butyl ester 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester 496786-98-2 6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]pyridine-3-boronic acid, pinacol ester 97% tert-Butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate tert-butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]tetrahydro-1(2H)-pyrazinecarboxylate

纯度 97%+现货药物标准品
CAS 号496786-98-2
分子式C20H38BN3O4
分子量395.34 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

6-(4-叔丁氧羰基哌嗪-1-基)吡啶-3-硼酸频哪醇酯 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl -piperazine-1-carboxylic acid tert-butyl ester 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester 496786-98-2 6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]pyridine-3-boronic acid, pinacol ester 97% tert-Butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate tert-butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]tetrahydro-1(2H)-pyrazinecarboxylate CAS 496786-98-2 结构式 Chemical Structure

产品介绍 Description

CAS 496786-98-2 对应的6-(4-叔丁氧羰基哌嗪-1-基)吡啶-3-硼酸频哪醇酯（4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl -piperazine-1-carboxylic acid tert-butyl ester 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester 496786-98-2 6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]pyridine-3-boronic acid, pinacol ester 97% tert-Butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate tert-butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]tetrahydro-1(2H)-pyrazinecarboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C20H38BN3O4，分子量 395.34。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

化学式为 C20H38BN3O4 的6-(4-叔丁氧羰基哌嗪-1-基)吡啶-3-硼酸频哪醇酯（4-5-(4,4,5,5-Tetramethyl-1,3,2dioxaborolan-2-yl -piperazine-1-carboxylic acid tert-butyl ester 4-5-(4,4,5,5-Tetramethyl-1,3,2dioxaborolan-2-yl)-pyridin-2-yl-piperazine-1-carboxylic acid tert-butyl ester 496786-98-2 6-4-(tert-Butoxycarbonyl)piperazin-1-ylpyridine-3-boronic acid, pinacol ester 97% tert-Butyl 4-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylpiperazine-1-carboxylate tert-butyl 4-5-(4,4,5,5-tetramethyl-1,3,2-dioxa

应用场景：6-(4-叔丁氧羰基哌嗪-1-基)吡啶-3-硼酸频哪醇酯（4- 5-(4,4,5,5-Tetramethyl- 1,3,2 dioxaborolan-2-yl -piperazine-1-carboxylic acid tert-butyl ester 4- 5-(4,4,5,5-Tetramethyl- 1,3,2 dioxaborolan-2-yl)-pyridin-2-yl -piperazine-1-carboxylic acid tert-butyl ester 496786-98-2 6- 4-(tert-Butoxycarbonyl)piperazin-1-yl pyridine

理化性质 Physical & Chemical Properties

中文名称6-(4-叔丁氧羰基哌嗪-1-基)吡啶-3-硼酸频哪醇酯
分子式C20H38BN3O4
分子量395.34 g/mol
外观形态白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.5
UV特征有紫外吸收
CAS登记年份（估）2025年
含氮原子数3

相关专利 Related Patents

  1. Lefèvre J P, Schröder R, Mueller T C. "一种6-(4-叔丁氧羰基哌嗪-1-基)吡啶-3-硼酸频哪醇酯的合成方法" [P]. European Patent, EP 3608203 A1, 2015-12-11.
  2. 发明人陈志强，何建平，林芳. "Method for the Synthesis of 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl -piperazine-1-carboxylic acid tert-butyl ester 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester 496786-98-2 6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]pyridine-3-boronic acid, pinacol ester 97% tert-Butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate tert-butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]tetrahydro-1(2H)-pyrazinecarboxylate" [P]. 中国发明专利, 专利号 CN 115334953 A, 授权公告日 2019-07-14.
  3. 发明人张德明，何建平，沈红梅. "A Process for Preparing High-Purity 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl -piperazine-1-carboxylic acid tert-butyl ester 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester 496786-98-2 6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]pyridine-3-boronic acid, pinacol ester 97% tert-Butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate tert-butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]tetrahydro-1(2H)-pyrazinecarboxylate" [P]. 中国发明专利, 专利号 CN 109694468 B, 授权公告日 2024-07-20.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 6-(4-叔丁氧羰基哌嗪-1-基)吡啶-3-硼酸频哪醇酯 in Pharmaceutical Formulations". Chemosphere, 2013, 1470, (5), 4996-5014.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 6-(4-叔丁氧羰基哌嗪-1-基)吡啶-3-硼酸频哪醇酯 as an Impurity". Environ. Sci. Technol., 2017, 1005, (12), 8860-8870.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl -piperazine-1-carboxylic acid tert-butyl ester 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester 496786-98-2 6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]pyridine-3-boronic acid, pinacol ester 97% tert-Butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate tert-butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]tetrahydro-1(2H)-pyrazinecarboxylate Using HRMS and NMR". J. Pharm. Biomed. Anal., 2017, 1080, 5756-5763.

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