6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline CAS 517874-21-4

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline

纯度 97%+现货药物标准品
CAS 号517874-21-4
分子式C14H19BO4
分子量262.11 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline CAS 517874-21-4 结构式 Chemical Structure

产品介绍 Description

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline（英文名 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline，CAS 517874-21-4）属于药物标准品。分子式 C14H19BO4，分子量 262.11。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline的产生途径与其化学式中羧酸类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline（6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline），CAS注册编号 517874-21-4，化学分子式为 C14H19BO4，分子量 262.11 g/mol。 受分子结构中羧酸类，含羟基，含醚键的影响，6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline表现为类白色至淡黄色结晶性粉末。其固体形态的物理化学属性——包括262.11 g/mol的分子量—

应用场景：6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline（6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙

理化性质 Physical & Chemical Properties

中文名称6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline
分子式C14H19BO4
分子量262.11 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1984年

相关专利 Related Patents

  1. 发明人钱学锋，沈红梅，张德明. "一种6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline的合成方法" [P]. 中国发明专利, 专利号 CN 115162334 B, 授权公告日 2017-11-04.
  2. Fischer A B, Roberts E F, Lee S K. "Method for the Synthesis of 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline" [P]. US Patent, US 11444330 B2, 2022-08-12.
  3. 发明人钱学锋，罗永刚，徐明华. "A Process for Preparing High-Purity 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline" [P]. 中国发明专利, 专利号 CN 108175587 B, 授权公告日 2024-05-22.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline in Pharmaceutical Formulations". Environ. Sci. Technol., 2025, 1179, (1), 6411-6424.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline as an Impurity". Chemosphere, 2014, 1366, (8), 1074-1084.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline Using HRMS and NMR". Biomed. Chromatogr., 2016, 1330, (5), 1132-1135.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo-1,4-dioxoline Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2021, 1975, 4281-4284.

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