<I>t</I>BuXPhos CAS 564483-19-8

2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl 564483-19-8 2-DI-T-BUTYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2,4,6-TRIISOPROPYLBIPHENYL;DI-T-BU-XPHOS;DI-TERT-BUTYL(2',4',6'-TRIISOPROPYL-[1,1'-BIPHENYL]-2-YL)PHOSPHINE;DI-TERT-BUTYL(2',4',6'-TRIISOPROPYLBIPHENYL-2-YL)PHOSPHINE;T-BUTYLXPHOS;TBUXPHOS;TERT-BUTYL XPHOS GC10151

纯度 97%+现货药物标准品
CAS 号564483-19-8
分子式C29H57P
分子量436.74 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

<I>t</I>BuXPhos 2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl 564483-19-8 2-DI-T-BUTYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2,4,6-TRIISOPROPYLBIPHENYL;DI-T-BU-XPHOS;DI-TERT-BUTYL(2',4',6'-TRIISOPROPYL-[1,1'-BIPHENYL]-2-YL)PHOSPHINE;DI-TERT-BUTYL(2',4',6'-TRIISOPROPYLBIPHENYL-2-YL)PHOSPHINE;T-BUTYLXPHOS;TBUXPHOS;TERT-BUTYL XPHOS GC10151 CAS 564483-19-8 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品<I>t</I>BuXPhos（2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl 564483-19-8 2-DI-T-BUTYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2,4,6-TRIISOPROPYLBIPHENYL;DI-T-BU-XPHOS;DI-TERT-BUTYL(2',4',6'-TRIISOPROPYL-[1,1'-BIPHENYL]-2-YL)PHOSPHINE;DI-TERT-BUTYL(2',4',6'-TRIISOPROPYLBIPHENYL-2-YL)PHOSPHINE;T-BUTYLXPHOS;TBUXPHOS;TERT-BUTYL XPHOS GC10151，CAS 564483-19-8），分子式 C29H57P，分子量 436.74。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 <I>t</I>BuXPhos（2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl 564483-19-8 2-DI-T-BUTYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2,4,6-TRIISOPROPYLBIPHENYL;DI-T-BU-XPHOS;DI-TERT-BUTYL(2',4',6'-TRIISOPROPYL-1,1'-BIPHENYL-2-YL)PHOSPHINE;DI-TER

应用场景：针对化学分析用途，<I>t</I>BuXPhos（2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl 564483-19-8 2-DI-T-BUTYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2,4,6-TRIISOPROPYLBIPHENYL;DI-T-BU-XPHOS;DI-TERT-BUTYL(2',4',6'-TRI

理化性质 Physical & Chemical Properties

中文名称<I>t</I>BuXPhos
分子式C29H57P
分子量436.74 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件室温保存
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.5
CAS登记年份（估）1984年

相关专利 Related Patents

  1. Sørensen M, Rossi M, Mueller T C. "一种<I>t</I>BuXPhos的合成方法" [P]. European Patent, EP 3611069 A1, 2015-02-02.
  2. 发明人唐晓军，郑宇鹏，韩伟. "Method for the Synthesis of 2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl 564483-19-8 2-DI-T-BUTYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2,4,6-TRIISOPROPYLBIPHENYL;DI-T-BU-XPHOS;DI-TERT-BUTYL(2',4',6'-TRIISOPROPYL-[1,1'-BIPHENYL]-2-YL)PHOSPHINE;DI-TERT-BUTYL(2',4',6'-TRIISOPROPYLBIPHENYL-2-YL)PHOSPHINE;T-BUTYLXPHOS;TBUXPHOS;TERT-BUTYL XPHOS GC10151" [P]. 中国发明专利, 专利号 CN 115748126 A, 授权公告日 2025-10-08.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of <I>t</I>BuXPhos in Pharmaceutical Formulations". Food Chem., 2010, 1226, 3415-3435.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of <I>t</I>BuXPhos as an Impurity". Anal. Chim. Acta, 2017, 2287, 4890-4906.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl 564483-19-8 2-DI-T-BUTYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL;2-DI-TERT-BUTYLPHOSPHINO-2,4,6-TRIISOPROPYLBIPHENYL;DI-T-BU-XPHOS;DI-TERT-BUTYL(2',4',6'-TRIISOPROPYL-[1,1'-BIPHENYL]-2-YL)PHOSPHINE;DI-TERT-BUTYL(2',4',6'-TRIISOPROPYLBIPHENYL-2-YL)PHOSPHINE;T-BUTYLXPHOS;TBUXPHOS;TERT-BUTYL XPHOS GC10151 Using HRMS and NMR". Phytochemistry, 2021, 1311, (6), 5212-5235.
  4. Kim S H, Park J Y. "Forced Degradation Studies to Evaluate <I>t</I>BuXPhos Profile in Drug Substances According to ICH Guidelines". Molecules, 2015, 1285, (12), 8024-8030.

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