6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one CAS 571159-02-9

6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one

纯度 97%+现货药物标准品
CAS 号571159-02-9
分子式C17H18N2OS2
分子量330.47 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one 6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one CAS 571159-02-9 结构式 Chemical Structure

产品介绍 Description

CAS 571159-02-9 对应的6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one（6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one）为 CATO 佳途药物标准品产品线成员。分子式 C17H18N2OS2，分子量 330.47。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno2,3-dpyrimidin-4-one的分子量为330.47 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C17H18N2OS2 的6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno2,3-dpyrimidin-4-one（6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno2,3-dpyrimidin-4-one），其CAS登记号是 571159-02-9，分子量为 330.47 g/mol。 6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno2,3-dpyrimidin-4-one（C17H18N2OS2）含有甾体骨架，酰胺类，含硫有机，含羟基，含醚键。较高的碳氢比使其脂溶性较好，这些物理化学性质直接决定

应用场景：6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno 2,3-d pyrimidin-4-one（6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno 2,3-d pyrimidin-4-one）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno 2,3-d pyrimidin-4-one配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议

理化性质 Physical & Chemical Properties

中文名称6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one
分子式C17H18N2OS2
分子量330.47 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1984年
含氮原子数2
含硫原子数2

相关专利 Related Patents

  1. 发明人朱建伟，周伟，杨光. "一种6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one的合成方法" [P]. 中国发明专利, 专利号 CN 110481704 A, 授权公告日 2023-09-25.
  2. Schröder R, O'Brien P Q, Davis P L. "Method for the Synthesis of 6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one" [P]. US Patent, US 11642608 B2, 2022-11-02.
  3. Anderson J P, Kumar R, Yamamoto T. "A Process for Preparing High-Purity 6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one" [P]. US Patent, US 11301734 B2, 2024-02-05.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one in Pharmaceutical Formulations". Biomed. Chromatogr., 2025, 2227, (11), 6707-6710.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one as an Impurity". Food Chem., 2011, 127, (12), 8943-8958.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one Using HRMS and NMR". J. Pharm. Biomed. Anal., 2017, 2397, 7637-7642.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 6-Ethyl-2-mercapto-5-methyl-3-(4-methyl-benzyl)-3H-thieno[2,3-d]pyrimidin-4-one Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2023, 2242, (1), 3444-3472.

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