(4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid CAS 608528-48-9

(4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid

纯度 97%+现货药物标准品
CAS 号608528-48-9
分子式C15H18B2O4S2
分子量348.05 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid (4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid CAS 608528-48-9 结构式 Chemical Structure

产品介绍 Description

(4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid（(4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid）是药物分析与质量控制领域常用的药物标准品，CAS 号 608528-48-9。分子式 C15H18B2O4S2，分子量 348.05。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

作为认证标准物质（CRM），(4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 CAS编号 608528-48-9 对应的化合物(4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid（英文标识 (4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid），化学式 C15H18B2O4S2，相对分子质量 348.05。 从化学结构特征来看，(4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid的分子骨架中包

应用场景：从实际应用出发，(4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid（CAS 608528-48-9）在化学分析中作为关键的基准对照物质。 推荐以(4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； -

理化性质 Physical & Chemical Properties

中文名称(4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid
分子式C15H18B2O4S2
分子量348.05 g/mol
外观形态类白色至淡黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1985年
含硫原子数2

相关专利 Related Patents

  1. 发明人孙丽萍，沈红梅，郭海燕. "一种(4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid的合成方法" [P]. 中国发明专利, 专利号 CN 115205564 B, 授权公告日 2023-07-18.
  2. O'Brien P Q, Thompson G K, Mueller T. "Method for the Synthesis of (4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid" [P]. US Patent, US 9834816 B2, 2025-11-21.
  3. 发明人沈红梅，钱学锋，郭海燕. "A Process for Preparing High-Purity (4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid" [P]. 中国发明专利, 专利号 CN 110163334 A, 授权公告日 2018-01-20.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of (4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid in Pharmaceutical Formulations". Sci. Total Environ., 2024, 427, 254-278.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of (4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid as an Impurity". J. Agric. Food Chem., 2012, 2400, 957-969.
  3. Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of (4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid Using HRMS and NMR". Molecules, 2016, 1795, (8), 8419-8441.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate (4,4-(cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))diboronic acid Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2014, 2156, 2785-2811.

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