3-((Z)-2-((3-(2-羧乙基)-5-(((R)-3-乙基-4-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-1H-吡咯-2-基)亚甲基)-5-(((R)-4-乙基-3-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-2H-吡咯-3-基)丙酸 CAS 6921-61-5
3-((Z)-2-((3-(2-Carboxyethyl)-5-(((R)-3-ethyl-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)methyl)-4-methyl-1H-pyrrol-2-yl)methylene)-5-(((R)-4-ethyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)methyl)-4-methyl-2H-pyrrol-3-yl)propanoic acid
| CAS 号 | 6921-61-5 |
| 分子式 | C33H42N4O6 |
| 分子量 | 590.71 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
3-((Z)-2-((3-(2-羧乙基)-5-(((R)-3-乙基-4-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-1H-吡咯-2-基)亚甲基)-5-(((R)-4-乙基-3-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-2H-吡咯-3-基)丙酸（3-((Z)-2-((3-(2-Carboxyethyl)-5-(((R)-3-ethyl-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)methyl)-4-methyl-1H-pyrrol-2-yl)methylene)-5-(((R)-4-ethyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)methyl)-4-methyl-2H-pyrrol-3-yl)propanoic acid）是药物分析与质量控制领域常用的药物标准品，CAS 号 6921-61-5。分子式 C33H42N4O6，分子量 590.71。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括3-((Z)-2-((3-(2-羧乙基)-5-(((R)-3-乙基-4-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-1H-吡咯-2-基)亚甲基)-5-(((R)-4-乙基-3-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-2H-吡咯-3-基)丙酸在内的目标物的控制。 化学式为 C33H42N4O6 的3-((Z)-2-((3-(2-羧乙基)-5-(((R)-3-乙基-4-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-1H-吡咯-2-基)亚甲基)-5-(((R)-4-乙基-3-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-2H-吡咯-3-基)丙酸（3-((Z)-2-((3-(2-Carboxyethyl)-5-(((R)-3-ethyl-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)methyl)-4-methyl-1H-pyrrol-2-yl)methylene)-5-(((R)-4-ethyl-3
应用场景：3-((Z)-2-((3-(2-羧乙基)-5-(((R)-3-乙基-4-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-1H-吡咯-2-基)亚甲基)-5-(((R)-4-乙基-3-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-2H-吡咯-3-基)丙酸（3-((Z)-2-((3-(2-Carboxyethyl)-5-(((R)-3-ethyl-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)methyl)-4-methyl-1H-pyrrol-2-yl)methylene)-5-(((R)-4-ethyl-3-meth
理化性质 Physical & Chemical Properties
| 中文名称 | 3-((Z)-2-((3-(2-羧乙基)-5-(((R)-3-乙基-4-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-1H-吡咯-2-基)亚甲基)-5-(((R)-4-乙基-3-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-2H-吡咯-3-基)丙酸 |
| 分子式 | C33H42N4O6 |
| 分子量 | 590.71 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 15.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1958年 |
| 含氮原子数 | 4 |
相关专利 Related Patents
- 发明人郭海燕，张德明，胡光. "一种3-((Z)-2-((3-(2-羧乙基)-5-(((R)-3-乙基-4-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-1H-吡咯-2-基)亚甲基)-5-(((R)-4-乙基-3-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-2H-吡咯-3-基)丙酸的合成方法" [P]. 中国发明专利, 专利号 CN 110880573 A, 授权公告日 2024-11-11.
- Sørensen M, Björnsson E, Jørgensen K. "Method for the Synthesis of 3-((Z)-2-((3-(2-Carboxyethyl)-5-(((R)-3-ethyl-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)methyl)-4-methyl-1H-pyrrol-2-yl)methylene)-5-(((R)-4-ethyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)methyl)-4-methyl-2H-pyrrol-3-yl)propanoic acid" [P]. European Patent, EP 3539023 A1, 2024-12-12.
参考文献 Literature
- Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 3-((Z)-2-((3-(2-羧乙基)-5-(((R)-3-乙基-4-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-1H-吡咯-2-基)亚甲基)-5-(((R)-4-乙基-3-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-2H-吡咯-3-基)丙酸 in Pharmaceutical Formulations". Chemosphere, 2013, 1575, 8491-8508.
- Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-((Z)-2-((3-(2-羧乙基)-5-(((R)-3-乙基-4-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-1H-吡咯-2-基)亚甲基)-5-(((R)-4-乙基-3-甲基-5-氧代-2,5-二氢-1H-吡咯-2-基)甲基)-4-甲基-2H-吡咯-3-基)丙酸 as an Impurity". J. Sep. Sci., 2018, 1265, (2), 4149-4168.
- Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of 3-((Z)-2-((3-(2-Carboxyethyl)-5-(((R)-3-ethyl-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)methyl)-4-methyl-1H-pyrrol-2-yl)methylene)-5-(((R)-4-ethyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)methyl)-4-methyl-2H-pyrrol-3-yl)propanoic acid Using HRMS and NMR". J. Nat. Prod., 2024, 506, 2302-2317.
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