Kolliphor<SUP>®</SUP> HS 15 CAS 70142-34-6

71YMM1X75O 70142-34-6 Polyoxyl 15 hydroxystearate [NF] Octadecanoic acid, 12-hydroxy-, polymer with alpha-hydro-omega-hydroxypoly(oxy-1,2-ethanediyl) Polyoxyl 15 hydroxystearate UNII-71YMM1X75O 12-Hydroxystearic acid-polyethylene glycol copolymer, minimum number average molecular weight (in amu), 3,690

纯度 97%+现货药物标准品
CAS 号70142-34-6
分子式C47H94O19
分子量963.24 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Kolliphor<SUP>®</SUP> HS 15 71YMM1X75O 70142-34-6 Polyoxyl 15 hydroxystearate [NF] Octadecanoic acid, 12-hydroxy-, polymer with alpha-hydro-omega-hydroxypoly(oxy-1,2-ethanediyl) Polyoxyl 15 hydroxystearate UNII-71YMM1X75O 12-Hydroxystearic acid-polyethylene glycol copolymer, minimum number average molecular weight (in amu), 3,690 CAS 70142-34-6 结构式 Chemical Structure

产品介绍 Description

CAS 70142-34-6 对应的Kolliphor<SUP>®</SUP> HS 15（71YMM1X75O 70142-34-6 Polyoxyl 15 hydroxystearate [NF] Octadecanoic acid, 12-hydroxy-, polymer with alpha-hydro-omega-hydroxypoly(oxy-1,2-ethanediyl) Polyoxyl 15 hydroxystearate UNII-71YMM1X75O 12-Hydroxystearic acid-polyethylene glycol copolymer, minimum number average molecular weight (in amu), 3,690）为 CATO 佳途药物标准品产品线成员。分子式 C47H94O19，分子量 963.24。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

Kolliphor<SUP>®</SUP> HS 15（分子式 C47H94O19）的化学结构中包含羧酸类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受官能团的极性和离子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。 CAS编号 70142-34-6 对应的化合物Kolliphor<SUP>®</SUP> HS 15（英文标识 71YMM1X75O 70142-34-6 Polyoxyl 15 hydroxystearate NF Octadecanoic acid, 12-hydroxy-, polymer with alpha-hydro-omega-hydroxypoly(oxy-1,2-ethanediyl) Polyoxyl 15 hydroxystearate UNII-71YMM1X75O 12-Hydroxystearic acid-polyethylene glycol copolymer, minimum number average molecular weight (in amu), 3,690），化学式 C47H94O

应用场景：针对化学分析用途，Kolliphor<SUP>®</SUP> HS 15（71YMM1X75O 70142-34-6 Polyoxyl 15 hydroxystearate NF Octadecanoic acid, 12-hydroxy-, polymer with alpha-hydro-omega-hydroxypoly(oxy-1,2-ethanediyl) Polyoxyl 15 hydroxystearate UNII-71YMM1X75O 12-Hydroxystearic acid-polyethylene glycol copolymer, minimum number

理化性质 Physical & Chemical Properties

中文名称Kolliphor<SUP>®</SUP> HS 15
分子式C47H94O19
分子量963.24 g/mol
外观形态白色至类白色无定形粉末
纯度97%+
储存条件室温保存，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1977年

相关专利 Related Patents

  1. Anderson J P, Hughes D C, O'Brien P Q. "一种Kolliphor<SUP>®</SUP> HS 15的合成方法" [P]. US Patent, US 11080620 B2, 2021-01-22.
  2. Lee S K, Park J H, Williams B T. "Method for the Synthesis of 71YMM1X75O 70142-34-6 Polyoxyl 15 hydroxystearate [NF] Octadecanoic acid, 12-hydroxy-, polymer with alpha-hydro-omega-hydroxypoly(oxy-1,2-ethanediyl) Polyoxyl 15 hydroxystearate UNII-71YMM1X75O 12-Hydroxystearic acid-polyethylene glycol copolymer, minimum number average molecular weight (in amu), 3,690" [P]. US Patent, US 11197392 B2, 2024-06-07.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of Kolliphor<SUP>®</SUP> HS 15 in Pharmaceutical Formulations". Environ. Sci. Technol., 2014, 347, 417-439.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of Kolliphor<SUP>®</SUP> HS 15 as an Impurity". Anal. Chem., 2010, 2237, (6), 238-248.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 71YMM1X75O 70142-34-6 Polyoxyl 15 hydroxystearate [NF] Octadecanoic acid, 12-hydroxy-, polymer with alpha-hydro-omega-hydroxypoly(oxy-1,2-ethanediyl) Polyoxyl 15 hydroxystearate UNII-71YMM1X75O 12-Hydroxystearic acid-polyethylene glycol copolymer, minimum number average molecular weight (in amu), 3,690 Using HRMS and NMR". Chemosphere, 2015, 2433, (2), 5225-5236.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate Kolliphor<SUP>®</SUP> HS 15 Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2025, 335, 7420-7427.

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