<I>O</I>,<I>O</I>′-二(三甲基甲硅烷基)胸苷 CAS 7288-28-0

7288-28-0 Pyrimidine, 5-methyl-2,4-bis(trimethylsiloxy)- (8CI) Pyrimidine, 5-methyl-2,4-bis((trimethylsilyl)oxy)- Bis(O-trimethylsilyl)thymine 2,4-Bis(trimethylsilyl)thymine 5-Methyl-2,4-bis(trimethylsiloxy)pyrimidine NSC 154616

纯度 97%+现货药物标准品
CAS 号7288-28-0
分子式C11H28N2O2Si2
分子量276.52 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

<I>O</I>,<I>O</I>′-二(三甲基甲硅烷基)胸苷 7288-28-0 Pyrimidine, 5-methyl-2,4-bis(trimethylsiloxy)- (8CI) Pyrimidine, 5-methyl-2,4-bis((trimethylsilyl)oxy)- Bis(O-trimethylsilyl)thymine 2,4-Bis(trimethylsilyl)thymine 5-Methyl-2,4-bis(trimethylsiloxy)pyrimidine NSC 154616 CAS 7288-28-0 结构式 Chemical Structure

产品介绍 Description

<I>O</I>,<I>O</I>′-二(三甲基甲硅烷基)胸苷（7288-28-0 Pyrimidine, 5-methyl-2,4-bis(trimethylsiloxy)- (8CI) Pyrimidine, 5-methyl-2,4-bis((trimethylsilyl)oxy)- Bis(O-trimethylsilyl)thymine 2,4-Bis(trimethylsilyl)thymine 5-Methyl-2,4-bis(trimethylsiloxy)pyrimidine NSC 154616）是药物分析与质量控制领域常用的药物标准品，CAS 号 7288-28-0。分子式 C11H28N2O2Si2，分子量 276.52。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

<I>O</I>,<I>O</I>′-二(三甲基甲硅烷基)胸苷的产生途径与其化学式中氨基酸衍生物，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C11H28N2O2Si2 的<I>O</I>,<I>O</I>′-二(三甲基甲硅烷基)胸苷（7288-28-0 Pyrimidine, 5-methyl-2,4-bis(trimethylsiloxy)- (8CI) Pyrimidine, 5-methyl-2,4-bis((trimethylsilyl)oxy)- Bis(O-trimethylsilyl)thymine 2,4-Bis(trimethylsilyl)thymine 5-Methyl-2,4-bis(trimethylsiloxy)pyrimidine NSC 154616），其CAS登记号是 7288-28-0，分子量为 276.52 g/mol。 受分子结构中氨基酸衍生物，酰胺类，含羟基，含醚键的影响，<I>O</I>,<I>O</I>′-二(三甲基甲硅烷基)胸苷表现为白色至类白色结晶性粉末。其固体形态的物理

应用场景：<I>O</I>,<I>O</I>′-二(三甲基甲硅烷基)胸苷（7288-28-0 Pyrimidine, 5-methyl-2,4-bis(trimethylsiloxy)- (8CI) Pyrimidine, 5-methyl-2,4-bis((trimethylsilyl)oxy)- Bis(O-trimethylsilyl)thymine 2,4-Bis(trimethylsilyl)thymine 5-Methyl-2,4-bis(trimethylsiloxy)pyrimidine NSC 154616）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以<I>O</I>

理化性质 Physical & Chemical Properties

中文名称<I>O</I>,<I>O</I>′-二(三甲基甲硅烷基)胸苷
分子式C11H28N2O2Si2
分子量276.52 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）-1.0
CAS登记年份（估）1959年
含氮原子数2

相关专利 Related Patents

  1. 发明人李文辉，郭海燕，韩伟. "一种<I>O</I>,<I>O</I>′-二(三甲基甲硅烷基)胸苷的合成方法" [P]. 中国发明专利, 专利号 CN 112007495 A, 授权公告日 2020-11-25.
  2. Davis P L, Williams B T, Thompson G K. "Method for the Synthesis of 7288-28-0 Pyrimidine, 5-methyl-2,4-bis(trimethylsiloxy)- (8CI) Pyrimidine, 5-methyl-2,4-bis((trimethylsilyl)oxy)- Bis(O-trimethylsilyl)thymine 2,4-Bis(trimethylsilyl)thymine 5-Methyl-2,4-bis(trimethylsiloxy)pyrimidine NSC 154616" [P]. US Patent, US 9891376 B2, 2024-10-19.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of <I>O</I>,<I>O</I>′-二(三甲基甲硅烷基)胸苷 in Pharmaceutical Formulations". Biomed. Chromatogr., 2021, 1198, (6), 7477-7492.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of <I>O</I>,<I>O</I>′-二(三甲基甲硅烷基)胸苷 as an Impurity". Anal. Methods, 2011, 1550, 3523-3528.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 7288-28-0 Pyrimidine, 5-methyl-2,4-bis(trimethylsiloxy)- (8CI) Pyrimidine, 5-methyl-2,4-bis((trimethylsilyl)oxy)- Bis(O-trimethylsilyl)thymine 2,4-Bis(trimethylsilyl)thymine 5-Methyl-2,4-bis(trimethylsiloxy)pyrimidine NSC 154616 Using HRMS and NMR". J. Nat. Prod., 2022, 1287, 5372-5389.

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