{3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester CAS 729574-24-7

{3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester

纯度 97%+现货药物标准品
CAS 号729574-24-7
分子式C15H14Cl2N2O4S
分子量389.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

{3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester {3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester CAS 729574-24-7 结构式 Chemical Structure

产品介绍 Description

CAS 729574-24-7 对应的{3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester（{3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester）为 CATO 佳途药物标准品产品线成员。分子式 C15H14Cl2N2O4S，分子量 389.25。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

化学式为 C15H14Cl2N2O4S 的{3-(3,4-Dichloro-phenylcarbamoyl)-methyl-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester（{3-(3,4-Dichloro-phenylcarbamoyl)-methyl-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester），其CAS登记号是 729574-24-7，分子量为 389.25 g/mol。 {3-(3,4-Dichloro-phenylcarbamoyl)-methyl-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester（C15H14Cl2N2O4S）含有黄酮骨架，酰胺类，含砜基，含羟基，含醚键，含氯取代。具有较强的吸湿性，卤素取代增加了化合物的密度和沸点，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫

应用场景：在化学分析实验室中，{3- (3,4-Dichloro-phenylcarbamoyl)-methyl -4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester（CAS 729574-24-7）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以{3- (3,4-Dichloro-phenylcarbamoyl)-methyl -4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备

理化性质 Physical & Chemical Properties

中文名称{3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester
分子式C15H14Cl2N2O4S
分子量389.25 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年
卤素含量Cl取代
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. O'Brien P Q, Brown S R, Mueller T. "一种{3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester的合成方法" [P]. US Patent, US 11048895 B2, 2017-08-22.
  2. Kowalski A, Martínez F, Sørensen M. "Method for the Synthesis of {3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester" [P]. European Patent, EP 3397734 A1, 2022-03-05.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of {3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2023, 1086, 8990-9015.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of {3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester as an Impurity". Anal. Chem., 2025, 264, 7832-7855.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of {3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-4-oxo-thiazolidin-2-ylidene}-acetic acid ethyl ester Using HRMS and NMR". Biomed. Chromatogr., 2017, 282, 5162-5192.

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