CHAPS CAS 75621-03-3

QBP25342AG 75621-03-3 CHAPS 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate 1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, hydroxide, inner salt 3-((3-Cholamidopropyl)dimethylammonio)-1-propanesulfonate Cholic acid sulfobetaine1-propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-, hydroxide, inner salt 1-Propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-,hydroxide, inner salt UNII-QBP25342AG

纯度 97%+现货药物标准品
CAS 号75621-03-3
分子式C32H58N2O7S
分子量614.88 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

CHAPS QBP25342AG 75621-03-3 CHAPS 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate 1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, hydroxide, inner salt 3-((3-Cholamidopropyl)dimethylammonio)-1-propanesulfonate Cholic acid sulfobetaine1-propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-, hydroxide, inner salt 1-Propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-,hydroxide, inner salt UNII-QBP25342AG CAS 75621-03-3 结构式 Chemical Structure

产品介绍 Description

CAS 75621-03-3 对应的CHAPS（QBP25342AG 75621-03-3 CHAPS 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate 1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, hydroxide, inner salt 3-((3-Cholamidopropyl)dimethylammonio)-1-propanesulfonate Cholic acid sulfobetaine1-propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-, hydroxide, inner salt 1-Propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-,hydroxide, inner salt UNII-QBP25342AG）为 CATO 佳途药物标准品产品线成员。分子式 C32H58N2O7S，分子量 614.88。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，CHAPS的分子量为614.88 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C32H58N2O7S 的CHAPS（QBP25342AG 75621-03-3 CHAPS 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate 1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, hydroxide, inner salt 3-((3-Cholamidopropyl)dimethylammonio)-1-propanesulfonate Cholic acid sulfobetaine1-propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-

应用场景：在化学分析实验室中，CHAPS（CAS 75621-03-3）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以CHAPS配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于阴凉处（≤25°C）保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称CHAPS
分子式C32H58N2O7S
分子量614.88 g/mol
外观形态类白色至淡黄色无定形粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1978年
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. Nielsen H, Lefèvre J P, Björnsson E. "一种CHAPS的合成方法" [P]. European Patent, EP 3680740 A1, 2020-03-13.
  2. Schröder R, Mueller T, Yamamoto T. "Method for the Synthesis of QBP25342AG 75621-03-3 CHAPS 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate 1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, hydroxide, inner salt 3-((3-Cholamidopropyl)dimethylammonio)-1-propanesulfonate Cholic acid sulfobetaine1-propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-, hydroxide, inner salt 1-Propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-,hydroxide, inner salt UNII-QBP25342AG" [P]. US Patent, US 9205499 B2, 2023-03-04.
  3. 发明人罗永刚，高志强，胡光. "A Process for Preparing High-Purity QBP25342AG 75621-03-3 CHAPS 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate 1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, hydroxide, inner salt 3-((3-Cholamidopropyl)dimethylammonio)-1-propanesulfonate Cholic acid sulfobetaine1-propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-, hydroxide, inner salt 1-Propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-,hydroxide, inner salt UNII-QBP25342AG" [P]. 中国发明专利, 专利号 CN 113527208 A, 授权公告日 2017-11-14.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of CHAPS in Pharmaceutical Formulations". Anal. Chim. Acta, 2016, 320, 6044-6052.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of CHAPS as an Impurity". Chromatographia, 2017, 124, (1), 8261-8283.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of QBP25342AG 75621-03-3 CHAPS 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate 1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, hydroxide, inner salt 3-((3-Cholamidopropyl)dimethylammonio)-1-propanesulfonate Cholic acid sulfobetaine1-propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-, hydroxide, inner salt 1-Propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-,hydroxide, inner salt UNII-QBP25342AG Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2019, 298, (7), 7609-7616.
  4. Martinez C, Lopez D R. "Forced Degradation Studies to Evaluate CHAPS Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2015, 1408, (12), 746-769.

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