3,3,3′,3′-四甲基-1,1′-螺旋联吲哚-5,5′,6,6′-四醇 CAS 77-08-7

77-08-7 1,1'-Spirobi(indan)-5,5',6,6'-tetrol, 3,3,3',3'-tetramethyl- (8CI) 1,1'-Spirobi(1H-indene)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 1,1'-Spirobi(1H-inden)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi(1H-indene)-5,5',6,6'-tetrol AI3-16787 EINECS 201-003-1 NSC 512922 1,1'-Spirobi(indane-5,6-diol), 3,3,3',3'-tetramethyl- TTS 5 AI 3-16787

纯度 97%+现货药物标准品
CAS 号77-08-7
分子式C21H36O4
分子量352.51 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3,3,3′,3′-四甲基-1,1′-螺旋联吲哚-5,5′,6,6′-四醇 77-08-7 1,1'-Spirobi(indan)-5,5',6,6'-tetrol, 3,3,3',3'-tetramethyl- (8CI) 1,1'-Spirobi(1H-indene)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 1,1'-Spirobi(1H-inden)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi(1H-indene)-5,5',6,6'-tetrol AI3-16787 EINECS 201-003-1 NSC 512922 1,1'-Spirobi(indane-5,6-diol), 3,3,3',3'-tetramethyl- TTS 5 AI 3-16787 CAS 77-08-7 结构式 Chemical Structure

产品介绍 Description

3,3,3′,3′-四甲基-1,1′-螺旋联吲哚-5,5′,6,6′-四醇（77-08-7 1,1'-Spirobi(indan)-5,5',6,6'-tetrol, 3,3,3',3'-tetramethyl- (8CI) 1,1'-Spirobi(1H-indene)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 1,1'-Spirobi(1H-inden)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi(1H-indene)-5,5',6,6'-tetrol AI3-16787 EINECS 201-003-1 NSC 512922 1,1'-Spirobi(indane-5,6-diol), 3,3,3',3'-tetramethyl- TTS 5 AI 3-16787，CAS 号 77-08-7）是 CATO 佳途自主生产的药物标准品，分子式 C21H36O4，分子量 352.51。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

3,3,3′,3′-四甲基-1,1′-螺旋联吲哚-5,5′,6,6′-四醇的产生途径与其化学式中甾体骨架，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 3,3,3′,3′-四甲基-1,1′-螺旋联吲哚-5,5′,6,6′-四醇（77-08-7 1,1'-Spirobi(indan)-5,5',6,6'-tetrol, 3,3,3',3'-tetramethyl- (8CI) 1,1'-Spirobi(1H-indene)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 1,1'-Spirobi(1H-inden)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi(1H-indene)-5,5',6,6'-tetrol AI3-16787 EINECS 201-003-1 NSC 5129

应用场景：针对化学分析用途，3,3,3′,3′-四甲基-1,1′-螺旋联吲哚-5,5′,6,6′-四醇（77-08-7 1,1'-Spirobi(indan)-5,5',6,6'-tetrol, 3,3,3',3'-tetramethyl- (8CI) 1,1'-Spirobi(1H-indene)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 1,1'-Spirobi(1H-inden)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 2,2',3,

理化性质 Physical & Chemical Properties

中文名称3,3,3′,3′-四甲基-1,1′-螺旋联吲哚-5,5′,6,6′-四醇
分子式C21H36O4
分子量352.51 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1957年

相关专利 Related Patents

  1. 发明人郑宇鹏，郭海燕，黄志刚. "一种3,3,3′,3′-四甲基-1,1′-螺旋联吲哚-5,5′,6,6′-四醇的合成方法" [P]. 中国发明专利, 专利号 CN 109336832 A, 授权公告日 2018-11-15.
  2. 发明人马晓峰，林芳，唐晓军. "Method for the Synthesis of 77-08-7 1,1'-Spirobi(indan)-5,5',6,6'-tetrol, 3,3,3',3'-tetramethyl- (8CI) 1,1'-Spirobi(1H-indene)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 1,1'-Spirobi(1H-inden)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi(1H-indene)-5,5',6,6'-tetrol AI3-16787 EINECS 201-003-1 NSC 512922 1,1'-Spirobi(indane-5,6-diol), 3,3,3',3'-tetramethyl- TTS 5 AI 3-16787" [P]. 中国发明专利, 专利号 CN 111517990 A, 授权公告日 2015-12-16.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 3,3,3′,3′-四甲基-1,1′-螺旋联吲哚-5,5′,6,6′-四醇 in Pharmaceutical Formulations". Phytochemistry, 2018, 230, (6), 1790-1817.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3,3,3′,3′-四甲基-1,1′-螺旋联吲哚-5,5′,6,6′-四醇 as an Impurity". J. Sep. Sci., 2015, 2086, 553-575.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 77-08-7 1,1'-Spirobi(indan)-5,5',6,6'-tetrol, 3,3,3',3'-tetramethyl- (8CI) 1,1'-Spirobi(1H-indene)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 1,1'-Spirobi(1H-inden)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi(1H-indene)-5,5',6,6'-tetrol AI3-16787 EINECS 201-003-1 NSC 512922 1,1'-Spirobi(indane-5,6-diol), 3,3,3',3'-tetramethyl- TTS 5 AI 3-16787 Using HRMS and NMR". Environ. Sci. Technol., 2010, 1249, (3), 3552-3575.

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