1-Boc-吲哚-5-硼酸频哪醇酯 CAS 777061-36-6

tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1-carboxylate 1-tert-butoxycarbonylindole-5-boronic acid, pinacol ester 1-tert-butoxycarbonyl-indole-5-boronic acid, pinacol ester n-boc-indole-5-boronic acid pinacol ester tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1 carboxylate tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole-1-carboxylate 1-Boc-indole-5-boronic acid pinacol ester 1-(tert-Butyloxy-carbonyl)-indole-5-boronic acid pinacol ester 777061-36-6

纯度 97%+现货药物标准品
CAS 号777061-36-6
分子式C19H34BNO4
分子量351.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-Boc-吲哚-5-硼酸频哪醇酯 tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1-carboxylate 1-tert-butoxycarbonylindole-5-boronic acid, pinacol ester 1-tert-butoxycarbonyl-indole-5-boronic acid, pinacol ester n-boc-indole-5-boronic acid pinacol ester tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1 carboxylate tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole-1-carboxylate 1-Boc-indole-5-boronic acid pinacol ester 1-(tert-Butyloxy-carbonyl)-indole-5-boronic acid pinacol ester 777061-36-6 CAS 777061-36-6 结构式 Chemical Structure

产品介绍 Description

1-Boc-吲哚-5-硼酸频哪醇酯（tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1-carboxylate 1-tert-butoxycarbonylindole-5-boronic acid, pinacol ester 1-tert-butoxycarbonyl-indole-5-boronic acid, pinacol ester n-boc-indole-5-boronic acid pinacol ester tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1 carboxylate tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole-1-carboxylate 1-Boc-indole-5-boronic acid pinacol ester 1-(tert-Butyloxy-carbonyl)-indole-5-boronic acid pinacol ester 777061-36-6，CAS 号 777061-36-6）是 CATO 佳途自主生产的药物标准品，分子式 C19H34BNO4，分子量 351.29。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

1-Boc-吲哚-5-硼酸频哪醇酯的产生途径与其化学式中酰胺类，羧酸类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 1-Boc-吲哚-5-硼酸频哪醇酯（tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1-carboxylate 1-tert-butoxycarbonylindole-5-boronic acid, pinacol ester 1-tert-butoxycarbonyl-indole-5-boronic acid, pinacol ester n-boc-indole-5-boronic acid pinacol ester tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1 carboxylate tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole-1-carboxylate 1-

应用场景：针对化学分析用途，1-Boc-吲哚-5-硼酸频哪醇酯（tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1-carboxylate 1-tert-butoxycarbonylindole-5-boronic acid, pinacol ester 1-tert-butoxycarbonyl-indole-5-boronic acid, pinacol ester n-boc-indole-5-boronic acid pinacol ester tert-butyl 5-(4,4,5,5-tetramethyl-1

理化性质 Physical & Chemical Properties

中文名称1-Boc-吲哚-5-硼酸频哪醇酯
分子式C19H34BNO4
分子量351.29 g/mol
外观形态白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.5
UV特征有紫外吸收
CAS登记年份（估）1986年
含氮原子数1

相关专利 Related Patents

  1. 发明人孙丽萍，李文辉，郑宇鹏. "一种1-Boc-吲哚-5-硼酸频哪醇酯的合成方法" [P]. 中国发明专利, 专利号 CN 117361620 A, 授权公告日 2015-09-13.
  2. 发明人王建平，杨光，郑宇鹏. "Method for the Synthesis of tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1-carboxylate 1-tert-butoxycarbonylindole-5-boronic acid, pinacol ester 1-tert-butoxycarbonyl-indole-5-boronic acid, pinacol ester n-boc-indole-5-boronic acid pinacol ester tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1 carboxylate tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole-1-carboxylate 1-Boc-indole-5-boronic acid pinacol ester 1-(tert-Butyloxy-carbonyl)-indole-5-boronic acid pinacol ester 777061-36-6" [P]. 中国发明专利, 专利号 CN 108648153 B, 授权公告日 2025-07-08.
  3. Lefèvre J P, Johansson L, Nielsen H. "A Process for Preparing High-Purity tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1-carboxylate 1-tert-butoxycarbonylindole-5-boronic acid, pinacol ester 1-tert-butoxycarbonyl-indole-5-boronic acid, pinacol ester n-boc-indole-5-boronic acid pinacol ester tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1 carboxylate tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole-1-carboxylate 1-Boc-indole-5-boronic acid pinacol ester 1-(tert-Butyloxy-carbonyl)-indole-5-boronic acid pinacol ester 777061-36-6" [P]. European Patent, EP 3504691 A1, 2021-03-27.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 1-Boc-吲哚-5-硼酸频哪醇酯 in Pharmaceutical Formulations". Anal. Methods, 2011, 1338, (8), 8143-8158.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-Boc-吲哚-5-硼酸频哪醇酯 as an Impurity". Environ. Sci. Technol., 2021, 962, (1), 2957-2979.

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