2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride CAS 878217-89-1

2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride

纯度 97%+现货药物标准品
CAS 号878217-89-1
分子式C10H11FN2O3S2
分子量290.33 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride 2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride CAS 878217-89-1 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride（2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride）为药物标准品，CAS 登记号 878217-89-1，分子式 C10H11FN2O3S2，分子量 290.33。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 化学式为 C10H11FN2O3S2 的2-(5,6-dimethyl-4-oxothieno2,3-dpyrimidin-3(4H)-yl)ethanesulfonyl fluoride（2-(5,6-dimethyl-4-oxothieno2,3-dpyrimidin-3(4H)-yl)ethanesulfonyl fluoride），其CAS登记号是 878217-89-1，分子量为 290.33 g/mol。 2-(5,6-dimethyl-4-oxothieno2,3-dpyrimidin-3(4H)-yl)ethanesulfonyl fluoride（分子式 C10H11FN2O3S2）的化学结构中包含含氮杂环结构，酰胺类，含砜基，含羟基，含醚键，含氟取代。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。卤素原子的引入增加了

应用场景：2-(5,6-dimethyl-4-oxothieno 2,3-d pyrimidin-3(4H)-yl)ethanesulfonyl fluoride（2-(5,6-dimethyl-4-oxothieno 2,3-d pyrimidin-3(4H)-yl)ethanesulfonyl fluoride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以2-(5,6-dimethyl-4-oxothieno 2,3-d pyrimidin-3(4H)-yl)ethanesulfonyl fluoride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制

理化性质 Physical & Chemical Properties

中文名称2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride
分子式C10H11FN2O3S2
分子量290.33 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
卤素含量F取代
含氮原子数2
含硫原子数2

相关专利 Related Patents

  1. 发明人李文辉，高志强，赵玉洁. "一种2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride的合成方法" [P]. 中国发明专利, 专利号 CN 115943683 A, 授权公告日 2022-10-10.
  2. Nowak P, Rossi M, Lefèvre J P. "Method for the Synthesis of 2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride" [P]. European Patent, EP 3365970 A1, 2016-10-27.
  3. Schröder R, Kowalski A, Rossi M. "A Process for Preparing High-Purity 2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride" [P]. European Patent, EP 3604337 A1, 2025-01-15.

参考文献 Literature

  1. Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride in Pharmaceutical Formulations". Chromatographia, 2017, 1829, (1), 7099-7123.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride as an Impurity". J. Agric. Food Chem., 2023, 1996, (5), 69-94.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride Using HRMS and NMR". Talanta, 2021, 164, 622-644.
  4. Kim S H, Park J Y. "Forced Degradation Studies to Evaluate 2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethanesulfonyl fluoride Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2017, 99, (4), 9460-9466.

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