<I>P</I>,<I>P</I>-双(2,2,2-三氟乙基)磷乙酸甲酯 CAS 88738-78-7

Bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl) phosphonate methyl p,p-bis(2,2,2-trifluoroethyl)phosphonoacetate bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate methyl p,p-bis(2,2,2trifluoroethyl)-phosphonoacetate bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate methyl o,o'-bis(2,2,2-trifluoroethyl)phosphonoacetate 88738-78-7

纯度 97%+现货药物标准品
CAS 号88738-78-7
分子式C7H9F6O5P
分子量318.11 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

<I>P</I>,<I>P</I>-双(2,2,2-三氟乙基)磷乙酸甲酯 Bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl) phosphonate methyl p,p-bis(2,2,2-trifluoroethyl)phosphonoacetate bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate methyl p,p-bis(2,2,2trifluoroethyl)-phosphonoacetate bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate methyl o,o'-bis(2,2,2-trifluoroethyl)phosphonoacetate 88738-78-7 CAS 88738-78-7 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品<I>P</I>,<I>P</I>-双(2,2,2-三氟乙基)磷乙酸甲酯（Bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl) phosphonate methyl p,p-bis(2,2,2-trifluoroethyl)phosphonoacetate bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate methyl p,p-bis(2,2,2trifluoroethyl)-phosphonoacetate bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate methyl o,o'-bis(2,2,2-trifluoroethyl)phosphonoacetate 88738-78-7，CAS 88738-78-7），分子式 C7H9F6O5P，分子量 318.11。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

<I>P</I>,<I>P</I>-双(2,2,2-三氟乙基)磷乙酸甲酯的产生途径与其化学式中含磷酸酯基，羧酸类，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 <I>P</I>,<I>P</I>-双(2,2,2-三氟乙基)磷乙酸甲酯（Bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl) phosphonate methyl p,p-bis(2,2,2-trifluoroethyl)phosphonoacetate bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate methyl p,p-bis(2,2,2trifluoroethyl)-phosphonoacetate bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate methyl o,o'-bis(2,2,2-trifluoroethyl)phosphonoacetate 88738-78-7），CAS

应用场景：<I>P</I>,<I>P</I>-双(2,2,2-三氟乙基)磷乙酸甲酯（Bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl) phosphonate methyl p,p-bis(2,2,2-trifluoroethyl)phosphonoacetate bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate methyl p,p-bis(2,2,2trifluoroethyl)-phosphonoacetate bis(2,2,2-trifluoroethyl) (methoxyca

理化性质 Physical & Chemical Properties

中文名称<I>P</I>,<I>P</I>-双(2,2,2-三氟乙基)磷乙酸甲酯
分子式C7H9F6O5P
分子量318.11 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件阴凉处（≤25°C）保存，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）0.5
CAS登记年份（估）1982年
卤素含量F取代

相关专利 Related Patents

  1. 发明人陈志强，马晓峰，赵玉洁. "一种<I>P</I>,<I>P</I>-双(2,2,2-三氟乙基)磷乙酸甲酯的合成方法" [P]. 中国发明专利, 专利号 CN 109966676 B, 授权公告日 2024-03-18.
  2. 发明人张德明，钱学锋，赵玉洁. "Method for the Synthesis of Bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl) phosphonate methyl p,p-bis(2,2,2-trifluoroethyl)phosphonoacetate bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate methyl p,p-bis(2,2,2trifluoroethyl)-phosphonoacetate bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate methyl o,o'-bis(2,2,2-trifluoroethyl)phosphonoacetate 88738-78-7" [P]. 中国发明专利, 专利号 CN 114882771 A, 授权公告日 2017-10-16.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of <I>P</I>,<I>P</I>-双(2,2,2-三氟乙基)磷乙酸甲酯 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2021, 2169, 9560-9584.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of <I>P</I>,<I>P</I>-双(2,2,2-三氟乙基)磷乙酸甲酯 as an Impurity". J. Agric. Food Chem., 2010, 2202, (5), 7948-7978.
  3. Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of Bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl) phosphonate methyl p,p-bis(2,2,2-trifluoroethyl)phosphonoacetate bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate methyl p,p-bis(2,2,2trifluoroethyl)-phosphonoacetate bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate methyl o,o'-bis(2,2,2-trifluoroethyl)phosphonoacetate 88738-78-7 Using HRMS and NMR". J. Pharm. Biomed. Anal., 2014, 1225, (2), 8248-8267.

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