1-[2-(cyclopentylamino)-2-oxoethyl]-3-cyclopropyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid CAS 1018142-65-8

1-[2-(cyclopentylamino)-2-oxoethyl]-3-cyclopropyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1018142-65-8
分子式C18H22N4O3
分子量342.39 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-[2-(cyclopentylamino)-2-oxoethyl]-3-cyclopropyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid 1-[2-(cyclopentylamino)-2-oxoethyl]-3-cyclopropyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid CAS 1018142-65-8 结构式 Chemical Structure

产品介绍 Description

1-[2-(cyclopentylamino)-2-oxoethyl]-3-cyclopropyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid（1-[2-(cyclopentylamino)-2-oxoethyl]-3-cyclopropyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid，CAS 号 1018142-65-8）是 CATO 佳途自主生产的药物标准品，分子式 C18H22N4O3，分子量 342.39。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

从化学结构特征来看，1-2-(cyclopentylamino)-2-oxoethyl-3-cyclopropyl-6-methyl-1H-pyrazolo3,4-bpyridine-4-carboxylic acid的分子骨架中包含甾体骨架，酰胺类，含羟基，含醚键。该化合物的不饱和度为10.0，表明结构中存在约10个环或双键等价单元。分子量为342.39 g/mol，属于较高分子量化合物。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 化学式为 C18H22N4O3 的1-2-(cyclopentylamino)-2-oxoethyl-3-cyclopropyl-6-methyl-1H-pyrazolo3,4-bpyridine-4-carboxylic acid（1-2-(cyclopentylamino)-2-oxoethyl-3-cyclopropyl-6-methyl-1H-pyrazolo3,4-bpyridine-4-carboxylic acid），其CAS登记号是 1018142-65-8，分子

应用场景：1- 2-(cyclopentylamino)-2-oxoethyl -3-cyclopropyl-6-methyl-1H-pyrazolo 3,4-b pyridine-4-carboxylic acid（1- 2-(cyclopentylamino)-2-oxoethyl -3-cyclopropyl-6-methyl-1H-pyrazolo 3,4-b pyridine-4-carboxylic acid）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以1- 2-(cyclopentylamino)-2-oxoethyl -3-cyclopropyl-6-methyl-1H

理化性质 Physical & Chemical Properties

中文名称1-[2-(cyclopentylamino)-2-oxoethyl]-3-cyclopropyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
分子式C18H22N4O3
分子量342.39 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数4

相关专利 Related Patents

  1. 发明人马晓峰，胡光，李文辉. "一种1-[2-(cyclopentylamino)-2-oxoethyl]-3-cyclopropyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 112864296 B, 授权公告日 2015-07-19.
  2. Kowalski A, Nielsen H, Johansson L. "Method for the Synthesis of 1-[2-(cyclopentylamino)-2-oxoethyl]-3-cyclopropyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid" [P]. European Patent, EP 3479472 A1, 2023-12-13.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 1-[2-(cyclopentylamino)-2-oxoethyl]-3-cyclopropyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid in Pharmaceutical Formulations". Talanta, 2024, 1643, (11), 9925-9952.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-[2-(cyclopentylamino)-2-oxoethyl]-3-cyclopropyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid as an Impurity". Anal. Chem., 2016, 964, 9531-9558.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of 1-[2-(cyclopentylamino)-2-oxoethyl]-3-cyclopropyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid Using HRMS and NMR". Anal. Chim. Acta, 2011, 1035, 5228-5258.
  4. Martinez C, Lopez D R. "Forced Degradation Studies to Evaluate 1-[2-(cyclopentylamino)-2-oxoethyl]-3-cyclopropyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2021, 649, (5), 9963-9989.

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