ethyl 2-amino-4-[(diethylamino)methyl]-5-[(methylamino)carbonyl]thiophene-3-carboxylate hydrobromide CAS 1177292-85-1

ethyl 2-amino-4-[(diethylamino)methyl]-5-[(methylamino)carbonyl]thiophene-3-carboxylate hydrobromide

纯度 97%+现货药物标准品
CAS 号1177292-85-1
分子式C14H23N3O3S HBr
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

ethyl 2-amino-4-[(diethylamino)methyl]-5-[(methylamino)carbonyl]thiophene-3-carboxylate hydrobromide ethyl 2-amino-4-[(diethylamino)methyl]-5-[(methylamino)carbonyl]thiophene-3-carboxylate hydrobromide CAS 1177292-85-1 结构式 Chemical Structure

产品介绍 Description

ethyl 2-amino-4-[(diethylamino)methyl]-5-[(methylamino)carbonyl]thiophene-3-carboxylate hydrobromide（英文名 ethyl 2-amino-4-[(diethylamino)methyl]-5-[(methylamino)carbonyl]thiophene-3-carboxylate hydrobromide，CAS 1177292-85-1）属于药物标准品。分子式 C14H23N3O3S HBr。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

ethyl 2-amino-4-(diethylamino)methyl-5-(methylamino)carbonylthiophene-3-carboxylate hydrobromide的产生途径与其化学式中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键，含溴取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C14H23N3O3S HBr 的ethyl 2-amino-4-(diethylamino)methyl-5-(methylamino)carbonylthiophene-3-carboxylate hydrobromide（ethyl 2-amino-4-(diethylamino)methyl-5-(methylamino)carbonylthiophene-3-carboxylate hydrobromide），其CAS登记号是 1177292-85-1，分子量为 394.33 g/mol。 ethyl 2-amino-4-(diethylamino)methyl-5-(methylamino)car

应用场景：从实际应用出发，ethyl 2-amino-4- (diethylamino)methyl -5- (methylamino)carbonyl thiophene-3-carboxylate hydrobromide（CAS 1177292-85-1）在化学分析中作为关键的基准对照物质。 推荐以ethyl 2-amino-4- (diethylamino)methyl -5- (methylamino)carbonyl thiophene-3-carboxylate hydrobromide配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液

理化性质 Physical & Chemical Properties

中文名称ethyl 2-amino-4-[(diethylamino)methyl]-5-[(methylamino)carbonyl]thiophene-3-carboxylate hydrobromide
分子式C14H23N3O3S HBr
分子量394.33 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
卤素含量Br取代
含氮原子数3
含硫原子数1

相关专利 Related Patents

  1. Roberts E F, Park J H, Klinger H. "一种ethyl 2-amino-4-[(diethylamino)methyl]-5-[(methylamino)carbonyl]thiophene-3-carboxylate hydrobromide的合成方法" [P]. US Patent, US 10981522 B2, 2018-01-23.
  2. 发明人徐明华，李文辉，杨光. "Method for the Synthesis of ethyl 2-amino-4-[(diethylamino)methyl]-5-[(methylamino)carbonyl]thiophene-3-carboxylate hydrobromide" [P]. 中国发明专利, 专利号 CN 108067723 B, 授权公告日 2022-02-11.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of ethyl 2-amino-4-[(diethylamino)methyl]-5-[(methylamino)carbonyl]thiophene-3-carboxylate hydrobromide in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2014, 704, 7157-7177.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of ethyl 2-amino-4-[(diethylamino)methyl]-5-[(methylamino)carbonyl]thiophene-3-carboxylate hydrobromide as an Impurity". J. Sep. Sci., 2010, 2297, 8980-8994.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of ethyl 2-amino-4-[(diethylamino)methyl]-5-[(methylamino)carbonyl]thiophene-3-carboxylate hydrobromide Using HRMS and NMR". Sci. Total Environ., 2017, 2001, 3211-3233.

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