methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate CAS 1221725-90-1

methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate

纯度 97%+现货药物标准品
CAS 号1221725-90-1
分子式C14H13N3O4
分子量287.27 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate CAS 1221725-90-1 结构式 Chemical Structure

产品介绍 Description

CAS 1221725-90-1 对应的methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate（methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C14H13N3O4，分子量 287.27。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate的分子量为287.27 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C14H13N3O4 的methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate（methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate），其CAS登记号是 1221725-90-1，分子量为 287.27 g/mol。 从化学结构特征来看，methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate的分子骨架中包含含氮杂环结构，酰胺类，含羟

应用场景：在化学分析实验室中，methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate（CAS 1221725-90-1）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀

理化性质 Physical & Chemical Properties

中文名称methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate
分子式C14H13N3O4
分子量287.27 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
含氮原子数3

相关专利 Related Patents

  1. Sørensen M, Jørgensen K, Mueller T C. "一种methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate的合成方法" [P]. European Patent, EP 3765025 A1, 2018-01-23.
  2. 发明人唐晓军，周伟，张德明. "Method for the Synthesis of methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate" [P]. 中国发明专利, 专利号 CN 110716069 B, 授权公告日 2022-09-01.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate in Pharmaceutical Formulations". J. Sep. Sci., 2013, 1169, (1), 7380-7385.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate as an Impurity". Phytochemistry, 2021, 2408, (8), 6965-6977.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate Using HRMS and NMR". Anal. Methods, 2022, 1735, 9693-9708.
  4. Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate methyl 1-(4-cyanophenyl)-4-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2016, 1210, 3172-3177.

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