3-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid CAS 1326810-45-0

3-(3,4-Dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1326810-45-0
分子式C11H9Cl2NO3
分子量274.10 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid 3-(3,4-Dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid CAS 1326810-45-0 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品3-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid（3-(3,4-Dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid，CAS 1326810-45-0），分子式 C11H9Cl2NO3，分子量 274.10。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

与同类药物标准品相比，3-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid的分子量为274.10 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 3-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid（3-(3,4-Dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid），CAS注册编号 1326810-45-0，化学分子式为 C11H9Cl2NO3，分子量 274.10 g/mol。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代的影响，3-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid表现为类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）。其固体形态的物理化学属性——包括27

应用场景：针对化学分析用途，3-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid（3-(3,4-Dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid）是具有明确定量溯源的认证级对照品。 推荐以3-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储

理化性质 Physical & Chemical Properties

中文名称3-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid
分子式C11H9Cl2NO3
分子量274.10 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. Davis P L, Williams B T, Fischer A B. "一种3-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid的合成方法" [P]. US Patent, US 10361297 B2, 2021-06-16.
  2. 发明人唐晓军，钱学锋，郑宇鹏. "Method for the Synthesis of 3-(3,4-Dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid" [P]. 中国发明专利, 专利号 CN 112488608 B, 授权公告日 2022-04-18.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 3-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2017, 465, (1), 2850-2868.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid as an Impurity". Talanta, 2023, 133, (10), 5273-5295.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 3-(3,4-Dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid Using HRMS and NMR". J. Nat. Prod., 2010, 1726, 5262-5268.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 3-(3,4-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Molecules, 2022, 2032, (11), 4773-4798.

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