2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate CAS 170861-68-4

2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate

纯度 97%+现货药物标准品
CAS 号170861-68-4
分子式C19H19NO4S
分子量357.42 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate 2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate CAS 170861-68-4 结构式 Chemical Structure

产品介绍 Description

2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate（2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate，CAS 号 170861-68-4）是 CATO 佳途自主生产的药物标准品，分子式 C19H19NO4S，分子量 357.42。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate的分子量为357.42 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 170861-68-4 对应的化合物2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate（英文标识 2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate），化学式 C19H19NO4S，相对分子质量 357.42。 受分子结构中黄酮骨架，酰胺类，含砜基，含羟基，含醚键的影响，2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate表现为淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）。其固体形态的物理化学属性——包括357.42 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。分子中的氮原子赋予该化合

应用场景：2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate（2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate，CAS 170861-68-4）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。

理化性质 Physical & Chemical Properties

中文名称2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate
分子式C19H19NO4S
分子量357.42 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2005年
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. Johnson M A, Lee S K, Roberts E F. "一种2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate的合成方法" [P]. US Patent, US 10966138 B2, 2016-09-26.
  2. Lefèvre J P, Johansson L, Mueller T C. "Method for the Synthesis of 2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate" [P]. European Patent, EP 3233254 A1, 2024-02-12.
  3. Hughes D C, Roberts E F, Chen K W. "A Process for Preparing High-Purity 2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate" [P]. US Patent, US 11585567 B2, 2019-10-17.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate in Pharmaceutical Formulations". Talanta, 2010, 1407, (9), 5585-5610.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate as an Impurity". J. Agric. Food Chem., 2018, 930, (9), 6840-6865.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate Using HRMS and NMR". J. Nat. Prod., 2025, 431, 4995-5011.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 2-(5-methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate Profile in Drug Substances According to ICH Guidelines". Molecules, 2021, 283, (6), 559-584.

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