3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine CAS 1803590-48-8

3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine

纯度 97%+现货药物标准品
CAS 号1803590-48-8
分子式C15H11BrF3NOS
分子量390.22 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine 3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine CAS 1803590-48-8 结构式 Chemical Structure

产品介绍 Description

3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine（3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine）是药物分析与质量控制领域常用的药物标准品，CAS 号 1803590-48-8。分子式 C15H11BrF3NOS，分子量 390.22。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

作为认证标准物质（CRM），3-2-bromo-4-(trifluoromethyl)benzoyl-4H,5H,6H-cyclopentabthiophen-2-amine满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C15H11BrF3NOS 的3-2-bromo-4-(trifluoromethyl)benzoyl-4H,5H,6H-cyclopentabthiophen-2-amine（3-2-bromo-4-(trifluoromethyl)benzoyl-4H,5H,6H-cyclopentabthiophen-2-amine），其CAS登记号是 1803590-48-8，分子量为 390.22 g/mol。 3-2-bromo-4-(trifluoromethyl)benzoyl-4H,5H,6H-cyclopentabthiophen-2-amine（C15H11BrF3NOS）含有

应用场景：3- 2-bromo-4-(trifluoromethyl)benzoyl -4H,5H,6H-cyclopenta b thiophen-2-amine（3- 2-bromo-4-(trifluoromethyl)benzoyl -4H,5H,6H-cyclopenta b thiophen-2-amine，CAS 1803590-48-8）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以3- 2-bromo-4-(trifluoromethyl)benzoyl -4H,5H,6H-cyclopenta b thiophen-2-amine配制标准系列工作溶液，用于建立标准曲线实现

理化性质 Physical & Chemical Properties

中文名称3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine
分子式C15H11BrF3NOS
分子量390.22 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量F/Br取代
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. Mueller T C, Schröder R, Johansson L. "一种3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine的合成方法" [P]. European Patent, EP 3029239 A1, 2021-02-22.
  2. 发明人黄志刚，冯建国，韩伟. "Method for the Synthesis of 3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine" [P]. 中国发明专利, 专利号 CN 108094645 A, 授权公告日 2016-05-08.
  3. 发明人郭海燕，胡光，陈志强. "A Process for Preparing High-Purity 3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine" [P]. 中国发明专利, 专利号 CN 111131336 B, 授权公告日 2018-07-18.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine in Pharmaceutical Formulations". Food Chem., 2022, 1832, 7266-7272.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine as an Impurity". J. Sep. Sci., 2010, 1596, (7), 4565-4589.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine Using HRMS and NMR". Chromatographia, 2012, 1598, (3), 1137-1155.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate 3-[2-bromo-4-(trifluoromethyl)benzoyl]-4H,5H,6H-cyclopenta[b]thiophen-2-amine Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2023, 1152, (3), 6495-6511.

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