2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,4’-piperidine]-5-yl}ethan-1-one CAS 1909306-51-9

2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,4’-piperidine]-5-yl}ethan-1-one

纯度 97%+现货药物标准品
CAS 号1909306-51-9
分子式C12H15F3N4O
分子量288.27 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,4’-piperidine]-5-yl}ethan-1-one 2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,4’-piperidine]-5-yl}ethan-1-one CAS 1909306-51-9 结构式 Chemical Structure

产品介绍 Description

2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,4’-piperidine]-5-yl}ethan-1-one（2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,4’-piperidine]-5-yl}ethan-1-one）是药物分析与质量控制领域常用的药物标准品，CAS 号 1909306-51-9。分子式 C12H15F3N4O，分子量 288.27。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

化学式为 C12H15F3N4O 的2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiroimidazo4,5-cpyridine-4,4’-piperidine-5-yl}ethan-1-one（2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiroimidazo4,5-cpyridine-4,4’-piperidine-5-yl}ethan-1-one），其CAS登记号是 1909306-51-9，分子量为 288.27 g/mol。 依据分子式为 C12H15F3N4O 的2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiroimidazo4,5-cpyridine-4,4’-piperidine-5-yl}ethan-1-one结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 288.27 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。卤素原子的引入增加了化合物的电负性

应用场景：针对化学分析用途，2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro imidazo 4,5-c pyridine-4,4’-piperidine -5-yl}ethan-1-one（2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro imidazo 4,5-c pyridine-4,4’-piperidine -5-yl}ethan-1-one）是具有明确定量溯源的认证级对照品。 推荐以2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro imidazo 4,5-c pyridine-4,4

理化性质 Physical & Chemical Properties

中文名称2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,4’-piperidine]-5-yl}ethan-1-one
分子式C12H15F3N4O
分子量288.27 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量F取代
含氮原子数4

相关专利 Related Patents

  1. Patel M V, Park J H, Thompson G K. "一种2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,4’-piperidine]-5-yl}ethan-1-one的合成方法" [P]. US Patent, US 9896657 B2, 2015-07-02.
  2. 发明人张德明，陈志强，孙丽萍. "Method for the Synthesis of 2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,4’-piperidine]-5-yl}ethan-1-one" [P]. 中国发明专利, 专利号 CN 109230534 A, 授权公告日 2024-04-04.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of 2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,4’-piperidine]-5-yl}ethan-1-one in Pharmaceutical Formulations". J. Sep. Sci., 2016, 838, (2), 5601-5619.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,4’-piperidine]-5-yl}ethan-1-one as an Impurity". Anal. Methods, 2010, 654, (3), 9667-9690.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,4’-piperidine]-5-yl}ethan-1-one Using HRMS and NMR". Sci. Total Environ., 2013, 672, 4049-4063.
  4. Wang L, Li J, Zhang H. "Forced Degradation Studies to Evaluate 2,2,2-trifluoro-1-{1,5,6,7-tetrahydrospiro[imidazo[4,5-c]pyridine-4,4’-piperidine]-5-yl}ethan-1-one Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2022, 1544, (8), 9818-9826.

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