2-二叔丁基膦-2′-(<I>N</I>,<I>N</I>-二甲氨基)联苯 CAS 224311-49-3

2-(Di-tert-butylphosphino)-2'-(N,N-dimethylamino)biphenyl 224311-49-3 2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYL-[1,1'-BIPHENYL]-2-AMINE;2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYLBIPHENYL-2-AMINE;2'-[BIS(1,1-DIMETHYLETHYL)PHOSPHINO]-N,N-DIMETHYL-[1,1'-BIPHENYL]-2-AMINE;2-(DI-TERT-BUTYLPHOSPHINO)-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-T-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-T-BUTYLPHOSPHINO-2-(N,N-DIMETHYLAMINO)BIPHENYL;T-BUDAVEPHOS;T-BUTYL DAVEPHOS;[2'-(DI-TERT-BUTYL-PHOSPHANYL)-BIPHENYL-2-YL]-DIMETHYL-AMINE GC10148

纯度 97%+现货药物标准品
CAS 号224311-49-3
分子式C22H44NP
分子量353.57 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-二叔丁基膦-2′-(<I>N</I>,<I>N</I>-二甲氨基)联苯 2-(Di-tert-butylphosphino)-2'-(N,N-dimethylamino)biphenyl 224311-49-3 2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYL-[1,1'-BIPHENYL]-2-AMINE;2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYLBIPHENYL-2-AMINE;2'-[BIS(1,1-DIMETHYLETHYL)PHOSPHINO]-N,N-DIMETHYL-[1,1'-BIPHENYL]-2-AMINE;2-(DI-TERT-BUTYLPHOSPHINO)-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-T-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-T-BUTYLPHOSPHINO-2-(N,N-DIMETHYLAMINO)BIPHENYL;T-BUDAVEPHOS;T-BUTYL DAVEPHOS;[2'-(DI-TERT-BUTYL-PHOSPHANYL)-BIPHENYL-2-YL]-DIMETHYL-AMINE GC10148 CAS 224311-49-3 结构式 Chemical Structure

产品介绍 Description

CAS 224311-49-3 对应的2-二叔丁基膦-2′-(<I>N</I>,<I>N</I>-二甲氨基)联苯（2-(Di-tert-butylphosphino)-2'-(N,N-dimethylamino)biphenyl 224311-49-3 2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYL-[1,1'-BIPHENYL]-2-AMINE;2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYLBIPHENYL-2-AMINE;2'-[BIS(1,1-DIMETHYLETHYL)PHOSPHINO]-N,N-DIMETHYL-[1,1'-BIPHENYL]-2-AMINE;2-(DI-TERT-BUTYLPHOSPHINO)-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-T-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-T-BUTYLPHOSPHINO-2-(N,N-DIMETHYLAMINO)BIPHENYL;T-BUDAVEPHOS;T-BUTYL DAVEPHOS;[2'-(DI-TERT-BUTYL-PHOSPHANYL)-BIPHENYL-2-YL]-DIMETHYL-AMINE GC10148）为 CATO 佳途药物标准品产品线成员。分子式 C22H44NP，分子量 353.57。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 2-二叔丁基膦-2′-(<I>N</I>,<I>N</I>-二甲氨基)联苯（2-(Di-tert-butylphosphino)-2'-(N,N-dimethylamino)biphenyl 224311-49-3 2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYL-1,1'-BIPHENYL-2-AMINE;2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYLBIPHENYL-2-AMINE;2'-BIS(1,1-DIMETHYLETHYL)PHOSPHINO-N,N-DIMETHYL-1,1'-BIPHENYL-2-AMINE;2-(DI-TERT-BUTYLPHOSPHINO)-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-T-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-

应用场景：针对化学分析用途，2-二叔丁基膦-2′-(<I>N</I>,<I>N</I>-二甲氨基)联苯（2-(Di-tert-butylphosphino)-2'-(N,N-dimethylamino)biphenyl 224311-49-3 2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYL- 1,1'-BIPHENYL -2-AMINE;2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYLBIPHENYL-2-AMINE;2'- BIS(1,1-DIMETHYLETHYL)PHOSPHINO -N,N-DIMETHYL- 1,1'-BIPHE

理化性质 Physical & Chemical Properties

中文名称2-二叔丁基膦-2′-(<I>N</I>,<I>N</I>-二甲氨基)联苯
分子式C22H44NP
分子量353.57 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.5
CAS登记年份（估）2021年
含氮原子数1

相关专利 Related Patents

  1. Jørgensen K, Mueller T C, Martínez F. "一种2-二叔丁基膦-2′-(<I>N</I>,<I>N</I>-二甲氨基)联苯的合成方法" [P]. European Patent, EP 3793781 A1, 2018-08-09.
  2. 发明人冯建国，徐明华，何建平. "Method for the Synthesis of 2-(Di-tert-butylphosphino)-2'-(N,N-dimethylamino)biphenyl 224311-49-3 2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYL-[1,1'-BIPHENYL]-2-AMINE;2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYLBIPHENYL-2-AMINE;2'-[BIS(1,1-DIMETHYLETHYL)PHOSPHINO]-N,N-DIMETHYL-[1,1'-BIPHENYL]-2-AMINE;2-(DI-TERT-BUTYLPHOSPHINO)-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-T-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-T-BUTYLPHOSPHINO-2-(N,N-DIMETHYLAMINO)BIPHENYL;T-BUDAVEPHOS;T-BUTYL DAVEPHOS;[2'-(DI-TERT-BUTYL-PHOSPHANYL)-BIPHENYL-2-YL]-DIMETHYL-AMINE GC10148" [P]. 中国发明专利, 专利号 CN 116839310 A, 授权公告日 2020-09-10.
  3. 发明人胡光，韩伟，郭海燕. "A Process for Preparing High-Purity 2-(Di-tert-butylphosphino)-2'-(N,N-dimethylamino)biphenyl 224311-49-3 2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYL-[1,1'-BIPHENYL]-2-AMINE;2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYLBIPHENYL-2-AMINE;2'-[BIS(1,1-DIMETHYLETHYL)PHOSPHINO]-N,N-DIMETHYL-[1,1'-BIPHENYL]-2-AMINE;2-(DI-TERT-BUTYLPHOSPHINO)-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-T-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-T-BUTYLPHOSPHINO-2-(N,N-DIMETHYLAMINO)BIPHENYL;T-BUDAVEPHOS;T-BUTYL DAVEPHOS;[2'-(DI-TERT-BUTYL-PHOSPHANYL)-BIPHENYL-2-YL]-DIMETHYL-AMINE GC10148" [P]. 中国发明专利, 专利号 CN 111431410 B, 授权公告日 2022-09-20.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 2-二叔丁基膦-2′-(<I>N</I>,<I>N</I>-二甲氨基)联苯 in Pharmaceutical Formulations". Anal. Methods, 2017, 85, (5), 8976-8991.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-二叔丁基膦-2′-(<I>N</I>,<I>N</I>-二甲氨基)联苯 as an Impurity". Molecules, 2019, 1878, (10), 1902-1918.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of 2-(Di-tert-butylphosphino)-2'-(N,N-dimethylamino)biphenyl 224311-49-3 2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYL-[1,1'-BIPHENYL]-2-AMINE;2'-(DI-TERT-BUTYLPHOSPHINO)-N,N-DIMETHYLBIPHENYL-2-AMINE;2'-[BIS(1,1-DIMETHYLETHYL)PHOSPHINO]-N,N-DIMETHYL-[1,1'-BIPHENYL]-2-AMINE;2-(DI-TERT-BUTYLPHOSPHINO)-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-T-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-DI-T-BUTYLPHOSPHINO-2-(N,N-DIMETHYLAMINO)BIPHENYL;T-BUDAVEPHOS;T-BUTYL DAVEPHOS;[2'-(DI-TERT-BUTYL-PHOSPHANYL)-BIPHENYL-2-YL]-DIMETHYL-AMINE GC10148 Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2017, 409, (7), 4484-4501.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 2-二叔丁基膦-2′-(<I>N</I>,<I>N</I>-二甲氨基)联苯 Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2012, 123, (4), 9260-9271.

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