DMT-dG(dmf) Phosphoramidite CAS 330628-04-1

330628-04-1 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; EBD296414 N2-dimethylformamidine-2'-deoxyguanosine-3'-diisopropylaminocyanoethyl phosphoramidite

纯度 97%+现货药物标准品
CAS 号330628-04-1
分子式C43H75N8O7P
分子量847.08 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

DMT-dG(dmf) Phosphoramidite 330628-04-1 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; EBD296414 N2-dimethylformamidine-2'-deoxyguanosine-3'-diisopropylaminocyanoethyl phosphoramidite CAS 330628-04-1 结构式 Chemical Structure

产品介绍 Description

DMT-dG(dmf) Phosphoramidite（330628-04-1 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; EBD296414 N2-dimethylformamidine-2'-deoxyguanosine-3'-diisopropylaminocyanoethyl phosphoramidite）是药物分析与质量控制领域常用的药物标准品，CAS 号 330628-04-1。分子式 C43H75N8O7P，分子量 847.08。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 CAS编号 330628-04-1 对应的化合物DMT-dG(dmf) Phosphoramidite（英文标识 330628-04-1 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-(2-cyanoethyl)-(N,N-diisopropyl)phosphoramidite 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-(2-cyanoethyl)-(N,N-diisopropyl)phosphoramidite; EBD296414 N2-dimethylformamidine-2'-deoxyguanosine-3'-diisopropylaminocyanoethyl phosphoramidite），化学式 C43H75N8O7P，相对分子质量

应用场景：DMT-dG(dmf) Phosphoramidite（330628-04-1 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'- (2-cyanoethyl)-(N,N-diisopropyl) phosphoramidite 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'- (2-cyanoethyl)-(N,N-diisopropyl) phosphoramidite; EBD296414 N2-di

理化性质 Physical & Chemical Properties

中文名称DMT-dG(dmf) Phosphoramidite
分子式C43H75N8O7P
分子量847.08 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
含氮原子数8

相关专利 Related Patents

  1. 发明人林芳，郭海燕，周伟. "一种DMT-dG(dmf) Phosphoramidite的合成方法" [P]. 中国发明专利, 专利号 CN 115176978 A, 授权公告日 2019-12-13.
  2. 发明人胡光，陈志强，林芳. "Method for the Synthesis of 330628-04-1 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; EBD296414 N2-dimethylformamidine-2'-deoxyguanosine-3'-diisopropylaminocyanoethyl phosphoramidite" [P]. 中国发明专利, 专利号 CN 114487729 B, 授权公告日 2016-03-13.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of DMT-dG(dmf) Phosphoramidite in Pharmaceutical Formulations". Anal. Chem., 2025, 2325, (5), 5094-5114.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of DMT-dG(dmf) Phosphoramidite as an Impurity". J. Pharm. Biomed. Anal., 2020, 125, (10), 6390-6416.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 330628-04-1 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite 5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; EBD296414 N2-dimethylformamidine-2'-deoxyguanosine-3'-diisopropylaminocyanoethyl phosphoramidite Using HRMS and NMR". Molecules, 2017, 1881, 5595-5611.

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