5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester CAS 351893-52-2

351893-52-2 5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester ethyl 5-chloro-4-hydroxy-8-methylquinoline-3-carboxylate

纯度 97%+现货药物标准品
CAS 号351893-52-2
分子式C13H22ClNO3
分子量275.77 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester 351893-52-2 5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester ethyl 5-chloro-4-hydroxy-8-methylquinoline-3-carboxylate CAS 351893-52-2 结构式 Chemical Structure

产品介绍 Description

CAS 351893-52-2 对应的5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester（351893-52-2 5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester ethyl 5-chloro-4-hydroxy-8-methylquinoline-3-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C13H22ClNO3，分子量 275.77。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester（351893-52-2 5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester ethyl 5-chloro-4-hydroxy-8-methylquinoline-3-carboxylate），CAS注册编号 351893-52-2，化学分子式为 C13H22ClNO3，分子量 275.77 g/mol。 从化学结构特征来看，5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester的分子骨架中包含酰胺类，羧酸类，含羟基，含醚键，含氯取代。该化合物的不饱和度为3.0，表明结构中存在约3个环或双键等价单元。分子量为275.77 g/mol，属于中等分子量化合物。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 在定量分析中，可作为校准标准或内标物使用，适用于

应用场景：针对化学分析用途，5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester（351893-52-2 5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester ethyl 5-chloro-4-hydroxy-8-methylquinoline-3-carboxylate）是具有明确定量溯源的认证级对照品。 推荐以5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester

理化性质 Physical & Chemical Properties

中文名称5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester
分子式C13H22ClNO3
分子量275.77 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）2025年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. 发明人钱学锋，沈红梅，黄志刚. "一种5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester的合成方法" [P]. 中国发明专利, 专利号 CN 114202728 B, 授权公告日 2019-11-17.
  2. 发明人刘建华，郑宇鹏，杨光. "Method for the Synthesis of 351893-52-2 5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester ethyl 5-chloro-4-hydroxy-8-methylquinoline-3-carboxylate" [P]. 中国发明专利, 专利号 CN 115562709 A, 授权公告日 2016-08-16.
  3. 发明人胡光，陈志强，何建平. "A Process for Preparing High-Purity 351893-52-2 5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester ethyl 5-chloro-4-hydroxy-8-methylquinoline-3-carboxylate" [P]. 中国发明专利, 专利号 CN 112939008 B, 授权公告日 2016-02-22.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of 5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester in Pharmaceutical Formulations". Talanta, 2022, 663, 7266-7276.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester as an Impurity". J. Nat. Prod., 2022, 1378, 7706-7723.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 351893-52-2 5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester ethyl 5-chloro-4-hydroxy-8-methylquinoline-3-carboxylate Using HRMS and NMR". Molecules, 2025, 696, (3), 8557-8577.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 5-Chloro-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2025, 589, (8), 8732-8751.

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