CAS 36017-64-8

(+/-)-Norgnoscopine (3S)-rel-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone 36017-64-8 N-Desmethyl Noscapine Nor-|A-gnoscopine Norgnoscopine

纯度 97%+现货药物标准品
CAS 号36017-64-8
分子式C21H21NO7
分子量399.39 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(+/-)-Norgnoscopine (3S)-rel-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone 36017-64-8 N-Desmethyl Noscapine Nor-|A-gnoscopine Norgnoscopine CAS 36017-64-8 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品（(+/-)-Norgnoscopine (3S)-rel-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone 36017-64-8 N-Desmethyl Noscapine Nor-|A-gnoscopine Norgnoscopine，CAS 36017-64-8），分子式 C21H21NO7，分子量 399.39。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

与同类药物标准品相比，的分子量为399.39 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C21H21NO7 的（(+/-)-Norgnoscopine (3S)-rel-6,7-Dimethoxy-3-(5R)-5,6,7,8-tetrahydro-4-methoxy-1,3-dioxolo4,5-gisoquinolin-5-yl-1(3H)-isobenzofuranone 36017-64-8 N-Desmethyl Noscapine Nor-|A-gnoscopine Norgnoscopine），其CAS登记号是 36017-64-8，分子量为 399.39 g/mol。 依据分子式为 C21H21NO7 的结构特征，其分子内含黄酮骨架，酰胺类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 399.39 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 本品适用于HPLC、GC、L

应用场景：针对化学分析用途，（(+/-)-Norgnoscopine (3S)-rel-6,7-Dimethoxy-3- (5R)-5,6,7,8-tetrahydro-4-methoxy-1,3-dioxolo 4,5-g isoquinolin-5-yl -1(3H)-isobenzofuranone 36017-64-8 N-Desmethyl Noscapine Nor-|A-gnoscopine Norgnoscopine）是具有明确定量溯源的认证级对照品。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀

理化性质 Physical & Chemical Properties

中文名称
分子式C21H21NO7
分子量399.39 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）12.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1967年
含氮原子数1

相关专利 Related Patents

  1. Fischer A B, Mueller T, Brown S R. "一种的合成方法" [P]. US Patent, US 11749304 B2, 2020-11-09.
  2. 发明人赵玉洁，刘建华，冯建国. "Method for the Synthesis of (+/-)-Norgnoscopine (3S)-rel-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone 36017-64-8 N-Desmethyl Noscapine Nor-|A-gnoscopine Norgnoscopine" [P]. 中国发明专利, 专利号 CN 110130578 A, 授权公告日 2019-07-06.
  3. Sørensen M, Nielsen H, Kowalski A. "A Process for Preparing High-Purity (+/-)-Norgnoscopine (3S)-rel-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone 36017-64-8 N-Desmethyl Noscapine Nor-|A-gnoscopine Norgnoscopine" [P]. European Patent, EP 3082289 A1, 2018-05-20.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Talanta, 2010, 2369, (10), 2639-2646.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Food Chem., 2021, 1850, (12), 2854-2879.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of (+/-)-Norgnoscopine (3S)-rel-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone 36017-64-8 N-Desmethyl Noscapine Nor-|A-gnoscopine Norgnoscopine Using HRMS and NMR". Anal. Methods, 2020, 1289, (9), 1826-1855.

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