methyl 6-hydroxy-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate CAS 380419-63-6
methyl 6-hydroxy-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate
| CAS 号 | 380419-63-6 |
| 分子式 | C10H6F3NO3S |
| 分子量 | 277.22 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CATO 佳途供应的methyl 6-hydroxy-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate（methyl 6-hydroxy-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate）为药物标准品，CAS 登记号 380419-63-6，分子式 C10H6F3NO3S，分子量 277.22。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。
methyl 6-hydroxy-4-(trifluoromethyl)thieno2,3-bpyridine-2-carboxylate的产生途径与其化学式中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C10H6F3NO3S 的methyl 6-hydroxy-4-(trifluoromethyl)thieno2,3-bpyridine-2-carboxylate（methyl 6-hydroxy-4-(trifluoromethyl)thieno2,3-bpyridine-2-carboxylate），其CAS登记号是 380419-63-6，分子量为 277.22 g/mol。 从化学结构特征来看，methyl 6-hydroxy-4-(trifluoromethyl)thieno2,3-bpyridine-2-carboxylate的分子骨架中包含含氮杂环结构，酰胺类，含砜基，含羟基，含醚键，含氟取代。该化合物的不饱和度为7.0，表明结构中存在约7个环或双键等价单元。
应用场景：methyl 6-hydroxy-4-(trifluoromethyl)thieno 2,3-b pyridine-2-carboxylate（methyl 6-hydroxy-4-(trifluoromethyl)thieno 2,3-b pyridine-2-carboxylate）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以methyl 6-hydroxy-4-(trifluoromethyl)thieno 2,3-b pyridine-2-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐
理化性质 Physical & Chemical Properties
| 中文名称 | methyl 6-hydroxy-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate |
| 分子式 | C10H6F3NO3S |
| 分子量 | 277.22 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，含硫化合物特征性气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 7.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 2025年 |
| 卤素含量 | F取代 |
| 含氮原子数 | 1 |
| 含硫原子数 | 1 |
相关专利 Related Patents
- 发明人陈志强，高志强，林芳. "一种methyl 6-hydroxy-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 116980890 A, 授权公告日 2017-12-11.
- 发明人周伟，杨光，韩伟. "Method for the Synthesis of methyl 6-hydroxy-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate" [P]. 中国发明专利, 专利号 CN 116141030 B, 授权公告日 2017-08-20.
参考文献 Literature
- Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 6-hydroxy-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate in Pharmaceutical Formulations". J. Nat. Prod., 2013, 426, (1), 3860-3877.
- Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 6-hydroxy-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate as an Impurity". Phytochemistry, 2010, 1263, (2), 8178-8185.
- Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of methyl 6-hydroxy-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylate Using HRMS and NMR". Talanta, 2017, 1022, 7920-7924.
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