3,3′-二硫代二丙酸二(N-羟基丁二酰亚胺酯) CAS 57757-57-0
2,5-dioxopyrrolidin-1-yl 3-({3-[(2,5-dioxopyrrolidin-1-yl)oxy]-3-oxopropyl}disulfanyl)propanoate 57757-57-0 DTSP Di(N-succinimidyl) 3,3 inverted exclamation marka-dithiodipropionate Dithiobis(succinimidyl propionate) Lomant inverted exclamation mark s reagent
| CAS 号 | 57757-57-0 |
| 分子式 | C14H16N2O8S2 |
| 分子量 | 404.42 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
3,3′-二硫代二丙酸二(N-羟基丁二酰亚胺酯)（2,5-dioxopyrrolidin-1-yl 3-({3-[(2,5-dioxopyrrolidin-1-yl)oxy]-3-oxopropyl}disulfanyl)propanoate 57757-57-0 DTSP Di(N-succinimidyl) 3,3 inverted exclamation marka-dithiodipropionate Dithiobis(succinimidyl propionate) Lomant inverted exclamation mark s reagent）是药物分析与质量控制领域常用的药物标准品，CAS 号 57757-57-0。分子式 C14H16N2O8S2，分子量 404.42。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。
3,3′-二硫代二丙酸二(N-羟基丁二酰亚胺酯)（2,5-dioxopyrrolidin-1-yl 3-({3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl}disulfanyl)propanoate 57757-57-0 DTSP Di(N-succinimidyl) 3,3 inverted exclamation marka-dithiodipropionate Dithiobis(succinimidyl propionate) Lomant inverted exclamation mark s reagent），CAS注册编号 57757-57-0，化学分子式为 C14H16N2O8S2，分子量 404.42 g/mol。 受分子结构中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键的影响，3,3′-二硫代二丙酸二(N-羟基丁二酰亚胺酯)表现为淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）。其固体形态的物理化学属性——包括404.42 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。由于结构中存在共轭发色团
应用场景：针对化学分析用途，3,3′-二硫代二丙酸二(N-羟基丁二酰亚胺酯)（2,5-dioxopyrrolidin-1-yl 3-({3- (2,5-dioxopyrrolidin-1-yl)oxy -3-oxopropyl}disulfanyl)propanoate 57757-57-0 DTSP Di(N-succinimidyl) 3,3 inverted exclamation marka-dithiodipropionate Dithiobis(succinimidyl propionate) Lomant inverted exclamation mark s reagent）是具有明确定
理化性质 Physical & Chemical Properties
| 中文名称 | 3,3′-二硫代二丙酸二(N-羟基丁二酰亚胺酯) |
| 分子式 | C14H16N2O8S2 |
| 分子量 | 404.42 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末。（含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 8.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1973年 |
| 含氮原子数 | 2 |
| 含硫原子数 | 2 |
相关专利 Related Patents
- 发明人罗永刚，唐晓军，杨光. "一种3,3′-二硫代二丙酸二(N-羟基丁二酰亚胺酯)的合成方法" [P]. 中国发明专利, 专利号 CN 108764653 B, 授权公告日 2017-11-06.
- 发明人周伟，胡光，孙丽萍. "Method for the Synthesis of 2,5-dioxopyrrolidin-1-yl 3-({3-[(2,5-dioxopyrrolidin-1-yl)oxy]-3-oxopropyl}disulfanyl)propanoate 57757-57-0 DTSP Di(N-succinimidyl) 3,3 inverted exclamation marka-dithiodipropionate Dithiobis(succinimidyl propionate) Lomant inverted exclamation mark s reagent" [P]. 中国发明专利, 专利号 CN 111483798 B, 授权公告日 2019-08-22.
- 发明人刘建华，孙丽萍，韩伟. "A Process for Preparing High-Purity 2,5-dioxopyrrolidin-1-yl 3-({3-[(2,5-dioxopyrrolidin-1-yl)oxy]-3-oxopropyl}disulfanyl)propanoate 57757-57-0 DTSP Di(N-succinimidyl) 3,3 inverted exclamation marka-dithiodipropionate Dithiobis(succinimidyl propionate) Lomant inverted exclamation mark s reagent" [P]. 中国发明专利, 专利号 CN 117503958 A, 授权公告日 2015-09-09.
参考文献 Literature
- Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 3,3′-二硫代二丙酸二(N-羟基丁二酰亚胺酯) in Pharmaceutical Formulations". J. Agric. Food Chem., 2019, 2274, (3), 1566-1577.
- Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3,3′-二硫代二丙酸二(N-羟基丁二酰亚胺酯) as an Impurity". Environ. Sci. Technol., 2024, 1416, 2864-2887.
- Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 2,5-dioxopyrrolidin-1-yl 3-({3-[(2,5-dioxopyrrolidin-1-yl)oxy]-3-oxopropyl}disulfanyl)propanoate 57757-57-0 DTSP Di(N-succinimidyl) 3,3 inverted exclamation marka-dithiodipropionate Dithiobis(succinimidyl propionate) Lomant inverted exclamation mark s reagent Using HRMS and NMR". Phytochemistry, 2014, 1951, (11), 5839-5847.
- O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate 3,3′-二硫代二丙酸二(N-羟基丁二酰亚胺酯) Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2021, 787, (9), 8541-8544.
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